Changes in Event-Related Desynchronization and Synchronization during the Auditory Oddball Task in Schizophrenia Patients.

Q4 Medicine Open Neuroimaging Journal Pub Date : 2012-01-01 Epub Date: 2012-06-01 DOI:10.2174/1874440001206010026

Toshiro Fujimoto, Eiichi Okumura, Kouzou Takeuchi, Atsushi Kodabashi, Hiroaki Tanaka, Toshiaki Otsubo, Katsumi Nakamura, Masaki Sekine, Shinichiro Kamiya, Yuji Higashi, Miwa Tsuji, Susumu Shimooki, Toshiyo Tamura

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引用次数: 19

Abstract

Objective: We studied differences in the spatiotemporal dynamics of cortical oscillation across brain regions of patients with schizophrenia and normal subjects during the auditory oddball task using magnetoencephalography (MEG) and electroencephalography (EEG).

Methods: Ten right-handed male schizophrenia patients were studied. We used a newly developed adaptive spatial filtering algorithm optimized for robust source time-frequency reconstruction of MEG and EEG data, and obtained consecutive images in functional maps of event-related desynchronization (ERD) and synchronization (ERS) in theta, lower alpha (8-10 Hz), upper alpha (10-13 Hz), and beta bands.

Results: Beta ERD power at 750-1000 ms in patients was significantly increased in large right upper temporal and parietal regions and small upper portions of bilateral dorsal frontal and dorsal-medial parietal regions. Theta ERS power in schizophrenic patients during the oddball task was significantly increased in the left temporal pole at 250-500 ms, and was significantly increased in dorsal, medial frontal, and anterior portions of the anterior cingulate cortex in both hemispheres, and the left portion of lateral temporal regions at 500-750 ms, compared to the control group (family-wise error correction p<0.05). Lower alpha ERS power was significantly decreased in the right occipital region at 500-750 ms and in the right midline parietal and bilateral occipital regions at 750-1000 ms. Upper alpha ERS power was significantly decreased in right midline parietal and left occipital regions at 750-1000 ms.

Conclusions: ERD/ERS changes were noted in the left temporal pole and midline frontal and anterior cingulate cortex in theta ERS, occipital lobe in alpha ERS, and right temporal-frontal-parietal, midline frontal, and anterior cingulate cortex in beta ERD. These findings may reflect disturbances in interaction among active large neuronal groups and their communication with each other that may be related to abnormal cognitive and psychopathological function.

Significance: Study of ERD and ERS by time-frequency analyses using MEG is useful to clarify data processing dysfunction in schizophrenia.

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精神分裂症患者听觉怪球任务中事件相关非同步和同步的变化。

目的:利用脑磁图(MEG)和脑电图(EEG)研究精神分裂症患者和正常人在听怪球任务时脑皮质振荡时空动态的差异。方法:对10例男性右撇子精神分裂症患者进行研究。我们使用了一种新开发的自适应空间滤波算法，该算法针对MEG和EEG数据的鲁棒源时频重构进行了优化，并在theta、lower alpha (8-10 Hz)、upper alpha (10-13 Hz)和beta波段获得了事件相关去同步(ERD)和同步(ERS)的功能图。结果:750 ~ 1000 ms时患者右上颞叶和顶叶大区、双侧额背和顶叶背内侧小区β ERD功率显著升高。与对照组相比，在250-500 ms时，精神分裂症患者在左颞极的θ ERS功率显著增加，在500-750 ms时，双脑前扣带皮层的背侧、内侧额叶和前部以及左颞外侧区域的θ ERS功率显著增加(家庭误差校正)。ERD/ERS在theta ERS中可见左侧颞极、额中线和前扣带皮层，在alpha ERS中可见枕叶，在beta ERD中可见右侧颞额顶叶、额中线和前扣带皮层。这些发现可能反映了活跃的大神经元群之间的相互作用和相互交流的障碍，这可能与异常的认知和精神病理功能有关。意义:通过MEG的时频分析研究ERD和ERS有助于阐明精神分裂症的数据处理功能障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Neuroimaging Journal Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

0.70

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0.00%

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期刊介绍： The Open Neuroimaging Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, and letters in all important areas of brain function, structure and organization including neuroimaging, neuroradiology, analysis methods, functional MRI acquisition and physics, brain mapping, macroscopic level of brain organization, computational modeling and analysis, structure-function and brain-behavior relationships, anatomy and physiology, psychiatric diseases and disorders of the nervous system, use of imaging to the understanding of brain pathology and brain abnormalities, cognition and aging, social neuroscience, sensorimotor processing, communication and learning.