{"title":"DNA display of PNA-tagged ligands: a versatile strategy to screen libraries and control geometry of multidentate ligands.","authors":"Nicolas Winssinger","doi":"10.4161/adna.21108","DOIUrl":null,"url":null,"abstract":"<p><p>Over the past decade, several technologies have emerged to access nucleic acid-tagged libraries and select the fittest compound within such libraries. This perspective focuses on recent development with PNA-tagged small molecules displayed on DNA templates for screening purposes and to probe the optimal geometry in multivalent interactions.</p>","PeriodicalId":8444,"journal":{"name":"Artificial DNA: PNA & XNA","volume":"3 3","pages":"105-8"},"PeriodicalIF":0.0000,"publicationDate":"2012-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/adna.21108","citationCount":"8","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Artificial DNA: PNA & XNA","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4161/adna.21108","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 8
Abstract
Over the past decade, several technologies have emerged to access nucleic acid-tagged libraries and select the fittest compound within such libraries. This perspective focuses on recent development with PNA-tagged small molecules displayed on DNA templates for screening purposes and to probe the optimal geometry in multivalent interactions.
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