The common C49620T polymorphism in the sulfonylurea receptor gene SUR1 (ABCC8) in patients with gestational diabetes and subsequent glucose metabolism abnormalities.

Experimental Diabetes Research Pub Date : 2012-01-01 Epub Date: 2012-08-15 DOI:10.1155/2012/712617
Piotr Molęda, Agnieszka Bińczak-Kuleta, Katarzyna Homa, Krzysztof Safranow, Zbigniew Celewicz, Anhelli Syrenicz, Adam Stefański, Aneta Fronczyk, Lilianna Majkowska
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引用次数: 6

Abstract

Aim: The aim of this study is to investigate the relationship between the common C49620T polymorphism in the sulfonylurea receptor (SUR1) gene and glucose metabolism, β-cell secretory function and insulin resistance in women with a history of gestational diabetes (GDM).

Material and methods: Study group included 199 women, diagnosed GDM within the last 5-12 years and control group of comparable 50 women in whom GDM was excluded during pregnancy. Blood glucose and insulin levels were measured during oral glucose tolerance test. Indices of insulin resistance (HOMA-IR) and β-cell function (HOMA %B) were calculated. In all patients, the C49620T polymorphism in intron 15 of the SUR1 gene was determined.

Results: The distribution of the studied polymorphism in the two groups did not differ from each other (χ(2) = 0.34, P = 0.8425). No association between the distribution of polymorphisms and coexisting glucose metabolism disorders (χ(2) = 7,13, P = 0, 3043) was found. No association was also observed between the polymorphism and HOMA %B or HOMA-IR.

Conclusions: The polymorphism C49620T in the SUR1 gene is not associated with insulin resistance and/or insulin secretion in women with a history of GDM and does not affect the development of GDM, or the development of glucose intolerance in the studied population.

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妊娠期糖尿病及后续糖代谢异常患者磺脲受体基因SUR1 (ABCC8)常见C49620T多态性
目的:探讨磺酰脲受体(SUR1)基因C49620T共同多态性与妊娠期糖尿病(GDM)女性糖代谢、β细胞分泌功能及胰岛素抵抗的关系。材料和方法:研究组包括199名在过去5-12年内诊断为GDM的妇女,对照组包括50名在妊娠期未诊断为GDM的妇女。口服糖耐量试验时测定血糖和胰岛素水平。计算胰岛素抵抗指数(HOMA- ir)和β细胞功能指数(HOMA %B)。在所有患者中,确定了SUR1基因内含子15中的C49620T多态性。结果:两组间多态性分布无统计学差异(χ(2) = 0.34, P = 0.8425)。多态性分布与共存的糖代谢障碍之间无相关性(χ(2) = 7,13, P = 0,3043)。多态性与HOMA %B或HOMA- ir之间也未观察到关联。结论:SUR1基因C49620T多态性与有GDM病史的女性胰岛素抵抗和/或胰岛素分泌无关,也不影响研究人群中GDM的发展或葡萄糖耐受不良的发展。
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来源期刊
Experimental Diabetes Research
Experimental Diabetes Research 医学-内分泌学与代谢
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