Role of long-acting injectable second-generation antipsychotics in the treatment of first-episode schizophrenia: a clinical perspective.

IF 3.6 Q1 PSYCHIATRY Schizophrenia Research and Treatment Pub Date : 2012-01-01 Epub Date: 2012-05-07 DOI:10.1155/2012/764769
Radovan Přikryl, Hana Přikrylová Kučerová, Michaela Vrzalová, Eva Cešková
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引用次数: 31

Abstract

Approximately 80% of patients with the first-episode schizophrenia reach symptomatic remission after antipsychotic therapy. However, within two years most of them relapse, mainly due to low levels of insight into the illness and nonadherence to their oral medication. Therefore, although the formal data available is limited, many experts recommend prescribing long-acting injectable second-generation antipsychotics (mostly risperidone or alternatively paliperidone) in the early stages of schizophrenia, particularly in patients who have benefited from the original oral molecule in the past and agree to receive long-term injectable treatment. Early application of long-acting injectable second-generation antipsychotics can significantly reduce the risk of relapse in the future and thus improve not only the social and working potential of patients with schizophrenia but also their quality of life.

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长效注射第二代抗精神病药物在治疗首发精神分裂症中的作用:临床观察。
大约80%的首发精神分裂症患者在抗精神病药物治疗后症状缓解。然而,在两年内,他们中的大多数人复发,主要是由于对疾病的了解程度低和不坚持口服药物。因此,尽管可获得的正式数据有限,但许多专家建议在精神分裂症的早期阶段开具长效注射第二代抗精神病药物(主要是利培酮或替代帕利培酮),特别是那些过去曾受益于原始口服分子并同意接受长期注射治疗的患者。早期应用长效注射型第二代抗精神病药物可显著降低未来复发的风险,从而提高精神分裂症患者的社会和工作潜力,提高其生活质量。
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
期刊最新文献
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