The PPARα Agonist Fenofibrate Reduces Prepulse Inhibition Disruption in a Neurodevelopmental Model of Schizophrenia.

IF 3.6 Q1 PSYCHIATRY Schizophrenia Research and Treatment Pub Date : 2012-01-01 Epub Date: 2012-05-15 DOI:10.1155/2012/839853
Benjamin Rolland, Kevin Marche, Olivier Cottencin, Régis Bordet
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引用次数: 19

Abstract

Oxidative stress has been implicated in neurodevelopmental theories of schizophrenia. Antioxidant Peroxysome Proliferator-Activated Receptors α (PPARα) agonist fenofibrate has neuroprotective properties and could reverse early preclinical infringements that could trigger the illness. We have evaluated the neuroprotective interest of fenofibrate in a neurodevelopmental rat model of schizophrenia. The oxidative lesion induced by Kainic Acid (KA) injection at postnatal day (PND) 7 has previously been reported to disrupt Prepulse Inhibition (PPI) at PND56 but not at PND35. In 4 groups of 15 male rats each, KN (KA-PND7 + normal postweaning food), KF (KA-PND7 + fenofibrate 0.2% food), ON (saline-PND7 + normal food), and OF (saline + fenofibrate food), PPI was recorded at PND35 and PND56. Three levels of prepulse were used: 73 dB, 76 dB, and 82 dB for a pulse at 120 dB. Four PPI scores were analyzed: PPI73, PPI76, PPI82, and mean PPI (PPIm). Two-way ANOVAs were used to evaluate the effects of both factors (KA + fenofibrate), and, in case of significant results, intergroup Student's t-tests were performed. We notably found a significant difference (P < 0.05) in PPIm between groups KN and KF at PND56, which supposes that fenofibrate could be worthy of interest for early neuroprotection in schizophrenia.

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ppara激动剂非诺贝特在精神分裂症神经发育模型中减少脉冲前抑制中断。
氧化应激与精神分裂症的神经发育理论有关。抗氧化过氧体增殖物激活受体α (PPARα)激动剂非诺贝特具有神经保护特性,可以逆转可能引发疾病的早期临床前侵害。我们已经评估了非诺贝特在精神分裂症神经发育大鼠模型中的神经保护作用。此前有报道称,产后7天(PND)注射Kainic Acid (KA)诱导的氧化损伤会破坏PND56的预脉冲抑制(PPI),但不会破坏PND35。4组雄性大鼠,每组15只,分别为KN (KA-PND7 +断奶后正常食物)、KF (KA-PND7 +非诺贝特0.2%食物)、ON(盐- pnd7 +正常食物)和of(盐+非诺贝特食物),在PND35和PND56时记录PPI。预脉冲使用三个级别:73 dB, 76 dB和82 dB的脉冲在120 dB。分析四个PPI评分:PPI73、PPI76、PPI82和平均PPI (PPIm)。采用双因素方差分析来评估这两个因素(KA +非诺贝特)的影响,如果结果显著,则进行组间学生t检验。我们发现,在PND56时,KN组和KF组的PPIm有显著差异(P < 0.05),这表明非诺贝特可能值得对精神分裂症的早期神经保护感兴趣。
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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