Elevated serum levels of homocysteine as an early prognostic factor of psychiatric disorders in children and adolescents.

IF 3.6 Q1 PSYCHIATRY Schizophrenia Research and Treatment Pub Date : 2012-01-01 Epub Date: 2012-10-02 DOI:10.1155/2012/373261
Laura Kevere, Santa Purvina, Daiga Bauze, Marcis Zeibarts, Raisa Andrezina, Arnis Rizevs, Sergejs Jelisejevs, Linda Piekuse, Madara Kreile, Indulis Purvins
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引用次数: 24

Abstract

Background and Goal. The aim was to examine the serum levels of homocysteine (Hcy) and their associations with the methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism in patients with schizophrenia and mood disorders as well as controls. Materials and Methods. There were 198 patients: 82 with schizophrenia spectrum disorders, 22 with mood disorders, and 94 controls. The level of Hcy was determined by an isocratic high-performance liquid chromatography system. MTHFR C677T polymorphism was analysed using the restriction fragment length polymorphism-polymerase chain reaction method. Results. The average level of Hcy was 11.94 ± 5.6 μmol/L for patients with schizophrenia, 11.65 ± 3.3 μmol/L for patients with affective disorders, versus 6.80 ± 2.93 μmol/L in a control. The highest level of Hcy has been observed in patients with episodic-recurrent course of schizophrenia (11.30 ± 7.74 μmol/L), paranoid schizophrenia continuous (12.76 ± 5.25 μmol/L), and in patients with affective disorders (11.65 ± 3.26 μmol/L). An association between the MTHFR gene C677T polymorphism and Hcy level was found by linear regression analysis (r = 1.41, P = 0.029). Conclusions. The data indicate a link between Hcy levels and schizophrenia and mood disorders. No associations between the level of Hcy in patients with schizophrenia and mood disorders and the MTHFR C677T polymorphism were found.

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血清同型半胱氨酸水平升高是儿童和青少年精神疾病的早期预后因素。
背景和目标。目的是检测同型半胱氨酸(Hcy)的血清水平及其与精神分裂症和情绪障碍患者以及对照组中亚甲基四氢叶酸还原酶(MTHFR)基因C677T多态性的关系。材料与方法。共有198名患者:82名患有精神分裂症谱系障碍,22名患有情绪障碍,94名对照组。采用等压高效液相色谱法测定Hcy含量。采用限制性内切片段长度多态性-聚合酶链反应法分析MTHFR C677T多态性。结果。精神分裂症患者的Hcy平均水平为11.94±5.6 μmol/L,情感性障碍患者的Hcy平均水平为11.65±3.3 μmol/L,对照组为6.80±2.93 μmol/L。Hcy水平在发作-复发型精神分裂症患者(11.30±7.74 μmol/L)、偏执型精神分裂症持续性患者(12.76±5.25 μmol/L)和情感性障碍患者(11.65±3.26 μmol/L)中最高。线性回归分析发现MTHFR基因C677T多态性与Hcy水平存在相关性(r = 1.41, P = 0.029)。结论。数据表明,Hcy水平与精神分裂症和情绪障碍之间存在联系。未发现精神分裂症和心境障碍患者的Hcy水平与MTHFR C677T多态性之间存在关联。
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
期刊最新文献
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