Effect of estrogen and dietary loading on condylar cartilage.

Journal of orofacial pain Pub Date : 2012-01-01

Marko Orajärvi, Elina Puijola, Shi-Bin Yu, Xiaodong Liu, Petri Tiilikainen, Meiqing Wang, Aune Raustia, Pertti Pirttiniemi

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Abstract

Aims: To study the effect of estrogen deficiency and altered temporomandibular joint loading on the histomorphology of condylar cartilage and on the expression of types II and X collagen and matrix metalloproteinase-3 (MMP-3).

Methods: Thirty-six female rats were divided into four groups: ovariectomized rats on a normal diet, nonovariectomized control rats on a normal diet, ovariectomized rats on a soft diet, and nonovariectomized control rats on a soft diet. Ovariectomy was performed at the age of 60 days. Repeated-measures ANOVA was used to analyze the data.

Results: The condylar cartilage in the ovariectomized normal diet group showed a significantly higher number of cells than in the nonovariectomized control rats (P < .001). The proportional amount of MMP-3 expression was significantly higher in the ovariectomized rats than in the nonovariectomized control rats in both diet groups (P < .001). The area covered by types II and X collagen was significantly higher in the experimental groups than in the control groups (P < .01).

Conclusion: Condylar cartilage is sensitive to both estrogen level and dietary loading.

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雌激素和饲粮负荷对大鼠髁突软骨的影响。

目的:研究雌激素缺乏和颞下颌关节负荷改变对大鼠髁突软骨组织形态学及II型、X型胶原蛋白和基质金属蛋白酶-3 (MMP-3)表达的影响。方法:将36只雌性大鼠分为4组:正常饮食组、正常饮食组、软饮食组、软饮食组。在60天时进行卵巢切除术。采用重复测量方差分析对数据进行分析。结果:去卵巢正常饮食组大鼠髁突软骨细胞数量明显高于未去卵巢对照组(P < 0.001)。两组去卵巢大鼠中MMP-3的比例表达量均显著高于未去卵巢的对照组(P < 0.001)。试验组ⅱ型和X型胶原覆盖面积显著高于对照组(P < 0.01)。结论:髁突软骨对雌激素水平和膳食负荷均敏感。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of orofacial pain 医学-牙科与口腔外科

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>12 weeks