Correlation of intestinal microbiota with overweight and obesity in Kazakh school children.

IF 4.2 2区生物学 Q2 MICROBIOLOGY BMC Microbiology Pub Date : 2012-11-28 DOI:10.1186/1471-2180-12-283

Peiru Xu, Min Li, Jihong Zhang, Tao Zhang

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引用次数: 98

Abstract

Background: This study sought to investigate a possible correlation between the intestinal microbiota, Bacteroidetes and Firmicutes, and obesity in Kazakh school children, aged 7-13 (n = 175).

Results: Obese subjects had significantly greater systolic blood pressure, waist and hip circumference, as well as HOMA-IR as compared to normal and overweight participants. In addition, Bacteroides copy number and Bact/Firm ratios were significantly lower in the obese group as compared to the normal and overweight groups (P < 0.0167). This difference is only significant in girls, but not in boys when stratified by gender. Furthermore, a negative correlation between BMI and Bacteroidetes copy number (r = -0.18, P = 0.017) as well as Bact/Firm (r = -0.22, P = 0.003) was observed.

Conclusion: An association between reduced gut Bacteroidetes and Bact/Firm ratio with obesity in female Kazakh children was identified. Further studies are necessary to elucidate the mechanism behind these changes as well as the value of determining their presence for predicting obesity.

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哈萨克学龄儿童肠道菌群与超重和肥胖的相关性

背景:本研究旨在调查哈萨克斯坦7-13岁学龄儿童(n = 175)肠道微生物群、拟杆菌门和厚壁菌门与肥胖之间的可能相关性。结果:与正常和超重的受试者相比，肥胖受试者的收缩压、腰围和臀围以及HOMA-IR明显更高。肥胖组拟杆菌拷贝数和Bact/Firm比显著低于正常组和超重组(P < 0.0167)。这种差异仅在女孩中显著，而在按性别分层的男孩中则没有。此外，BMI与拟杆菌门拷贝数(r = -0.18, P = 0.017)和Bact/Firm (r = -0.22, P = 0.003)呈负相关。结论:确定了哈萨克女儿童肠道拟杆菌群减少和Bact/Firm比值与肥胖之间的关系。需要进一步的研究来阐明这些变化背后的机制，以及确定它们的存在对预测肥胖的价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Microbiology 生物-微生物学

CiteScore

7.20

自引率

0.00%

发文量

280

审稿时长

3 months

期刊介绍： BMC Microbiology is an open access, peer-reviewed journal that considers articles on analytical and functional studies of prokaryotic and eukaryotic microorganisms, viruses and small parasites, as well as host and therapeutic responses to them and their interaction with the environment.