Correlation between blood activin levels and clinical parameters of type 2 diabetes.

Experimental Diabetes Research Pub Date : 2012-01-01 Epub Date: 2012-12-16 DOI:10.1155/2012/410579
Hui Wu, Michael Wu, Yi Chen, Carolyn A Allan, David J Phillips, Mark P Hedger
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引用次数: 185

Abstract

Aims: Activins A and B, and their binding protein, follistatin, regulate glucose metabolism and inflammation. Consequently, their role in type 2 diabetes (T2D) was examined.

Methods: Blood was taken from fasted participants (34 males; 58 females; 50-75 years) with diabetes or during an oral glucose tolerance test (OGTT). Clinical parameters were assessed, and blood assayed for activins, follistatin, and C-reactive protein.

Results: Serum levels of activin A (93.3 ± 27.0 pg/mL, mean ± SD), B (81.8 ± 30.8 pg/mL), or follistatin (6.52 ± 3.15 ng/mL) were not different (P > 0.05) between subjects with normal OGTT (n = 39), impaired glucose tolerance and/or fasting glucose (n = 17), or T2D (n = 36). However, activin A and/or activin B were positively correlated with parameters of insulin resistance and T2D, including fasting glucose (P < 0.001), fasting insulin (P = 0.02), glycated hemoglobin (P = 0.003), and homeostasis model assessment of insulin resistance (HOMA-IR; P < 0.001). Follistatin was positively correlated with HOMA-IR alone (P = 0.01).

Conclusions: These data indicate that serum measurements of activin A, B, or follistatin cannot discriminate risk for T2D in individual patients, but the activins display a positive relationship with clinical parameters of the disease.

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血活化素水平与2型糖尿病临床参数的相关性
目的:激活素A和B及其结合蛋白卵泡抑素调节糖代谢和炎症。因此,研究了它们在2型糖尿病(T2D)中的作用。方法:从禁食的参与者(34名男性;58岁女性;50-75岁)糖尿病患者或口服葡萄糖耐量试验(OGTT)期间。评估临床参数,并检测血液中的激活素、卵泡抑素和c反应蛋白。结果:激活素A(93.3±27.0 pg/mL, mean±SD)、B(81.8±30.8 pg/mL)、卵泡抑素(6.52±3.15 ng/mL)水平在OGTT正常(n = 39)、糖耐量和/或空腹血糖受损(n = 17)、T2D (n = 36)受试者之间无显著差异(P > 0.05)。然而,激活素A和/或激活素B与胰岛素抵抗和T2D参数呈正相关,包括空腹血糖(P < 0.001)、空腹胰岛素(P = 0.02)、糖化血红蛋白(P = 0.003)和胰岛素抵抗的稳态模型评估(HOMA-IR;P < 0.001)。Follistatin与单独HOMA-IR呈正相关(P = 0.01)。结论:这些数据表明,血清中激活素A、B或卵泡抑素的测定不能区分个体患者患T2D的风险,但激活素与该病的临床参数呈正相关。
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来源期刊
Experimental Diabetes Research
Experimental Diabetes Research 医学-内分泌学与代谢
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