Animal models of post-ischemic forced use rehabilitation: methods, considerations, and limitations.

Jessica M Livingston-Thomas, R Andrew Tasker
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引用次数: 17

Abstract

Many survivors of stroke experience arm impairments, which can severely impact their quality of life. Forcing use of the impaired arm appears to improve functional recovery in post-stroke hemiplegic patients, however the mechanisms underlying improved recovery remain unclear. Animal models of post-stroke rehabilitation could prove critical to investigating such mechanisms, however modeling forced use in animals has proven challenging. Potential problems associated with reported experimental models include variability between stroke methods, rehabilitation paradigms, and reported outcome measures. Herein, we provide an overview of commonly used stroke models, including advantages and disadvantages of each with respect to studying rehabilitation. We then review various forced use rehabilitation paradigms, and highlight potential difficulties and translational problems. Lastly, we discuss the variety of functional outcome measures described by experimental researchers. To conclude, we outline ongoing challenges faced by researchers, and the importance of translational communication. Many stroke patients rely critically on rehabilitation of post-stroke impairments, and continued effort toward progression of rehabilitative techniques is warranted to ensure best possible treatment of the devastating effects of stroke.

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缺血后强迫使用康复的动物模型:方法、考虑和局限性。
许多中风幸存者会经历手臂损伤,这可能严重影响他们的生活质量。强制使用受损的手臂似乎可以改善中风后偏瘫患者的功能恢复,然而改善恢复的机制尚不清楚。中风后康复的动物模型对于研究这种机制至关重要,然而,在动物身上建立强迫使用的模型已被证明具有挑战性。与报道的实验模型相关的潜在问题包括卒中方法、康复范例和报道的结果测量之间的差异。在这里,我们提供了常用的中风模型的概述,包括优点和缺点,每一个方面的研究康复。然后,我们回顾了各种强迫使用康复范例,并强调了潜在的困难和翻译问题。最后,我们讨论了实验研究人员描述的各种功能结果测量。最后,我们概述了研究人员面临的持续挑战,以及翻译交流的重要性。许多脑卒中患者严重依赖脑卒中后损伤的康复,继续努力发展康复技术是必要的,以确保对脑卒中破坏性影响的最佳治疗。
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