Elevated rates of ADHD in mothers of children with comorbid ADHD and epilepsy.

Neuropsychiatry Pub Date : 2012-10-01 DOI:10.2217/npy.12.53
Joseph Gonzalez-Heydrich, Hesham M Hamoda, Laura Luna, Sneha Rao, James McClendon, Peter Rotella, Deborah Waber, Katherine Boyer, Steven V Faraone, Jane Whitney, Danielle Guild, Joseph Biederman
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Abstract

OBJECTIVES: To describe the prevalence of ADHD in mothers of children with comorbid ADHD and epilepsy (ADHD+E) and to compare ADHD symptoms in mothers with (Fam(+)) and without (Fam(-)) additional relative(s) with epilepsy. PATIENTS & METHODS: Mothers (n = 16) of children with ADHD+E were assessed by the Kiddie Schedule for Affective Disorders and Schizophrenia for School Age Children ADHD module and the ADHD Rating Scale IV. Information was collected on the presence (Fam(+)) or absence (Fam(-)) of first- or second-degree relatives with epilepsy in the sample. RESULTS: A total of 50% of mothers met the DSM-IV criteria for ADHD. ADHD was more prevalent in Fam(+) mothers (80%) compared with Fam(-) mothers (36%; p = 0.14). Fam(+) mothers had more current hyperactivity symptoms than Fam(-) mothers (p = 0.002), higher current ADHD severity (p = 0.02) and higher ADHD Rating Scale IV hyperactivity scores (p = 0.008). CONCLUSION: The prevalence of ADHD in mothers of children with ADHD+E is elevated in this pilot study, suggesting that ADHD symptoms in children with epilepsy and their mothers reflects shared familial genetic or environmental risks, potentially resulting in a higher prevalence of both disorders among family members. This is a pilot study and larger controlled studies are warranted.

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合并多动症和癫痫的儿童的母亲患多动症的比例升高。
目的描述合并多动症和癫痫(ADHD+E)儿童的母亲中多动症的患病率,并比较有(家族(+))和没有(家族(-))额外癫痫亲属的母亲的多动症症状。 患者与方法:通过学龄儿童情感障碍和精神分裂症多动症模块 Kiddie Schedule 和多动症评定量表 IV 对多动症+E 患儿的母亲(n = 16)进行评估。此外,还收集了样本中一级或二级亲属是否患有癫痫的信息。 结果:共有 50% 的母亲符合 DSM-IV 多动症标准。与家族(-)母亲(36%;P = 0.14)相比,多动症在家族(+)母亲(80%)中更为普遍。家族(+)母亲比家族(-)母亲有更多的多动症状(p = 0.002)、更高的多动症严重程度(p = 0.02)和更高的多动症量表 IV 多动评分(p = 0.008)。 结论:在这项试点研究中,ADHD+E 患儿母亲的 ADHD 患病率升高,这表明癫痫患儿及其母亲的 ADHD 症状反映了共同的家族遗传或环境风险,可能导致这两种疾病在家庭成员中的患病率升高。这只是一项试点研究,有必要进行更大规模的对照研究。
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Neuropsychiatry
Neuropsychiatry NEUROSCIENCES-PSYCHIATRY
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>12 weeks
期刊介绍: Neuropsychiatry is a bimonthly, peer reviewed, open access Journal aimed at exploring the latest breakthroughs in brain and behavior in order to enhance our current understanding of the disturbances in brain function. The Journal has established itself among the most authoritative journals in the field by publishing cutting-edge research in neuropsychiatry and also serves as a forum for discussing the latest advancements and problem statements in the field.
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