Atypical antipsychotics in the treatment of depressive and psychotic symptoms in patients with chronic schizophrenia: a naturalistic study.

IF 3.6 Q1 PSYCHIATRY Schizophrenia Research and Treatment Pub Date : 2013-01-01 Epub Date: 2013-01-21 DOI:10.1155/2013/423205
Marco Innamorati, Stefano Baratta, Cristina Di Vittorio, David Lester, Paolo Girardi, Maurizio Pompili, Mario Amore
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引用次数: 8

Abstract

Objectives. The aim of this naturalistic study was to investigate whether treatment with clozapine and other atypical antipsychotics for at least 2 years was associated with a reduction in psychotic and depressive symptoms and an improvement in chronic schizophrenia patients' awareness of their illness. Methods. Twenty-three adult outpatients (15 men and 8 women) treated with clozapine and 23 patients (16 men and 7 women) treated with other atypical antipsychotics were included in the study. Psychotic symptoms were evaluated using the Positive and Negative Syndrome Scale (PANSS), depressive symptoms were assessed with the Calgary Depression Scale for Schizophrenia (CDSS), and insight was assessed with the Scale to Assess Unawareness of Mental Disorder (SUMD). Results. The sample as a whole had a significant reduction in positive, negative, and general symptoms, whereas the reduction in depression was significant only for patients with CDSS scores of 5 and higher at the baseline. At the follow-up, patients treated with other atypical antipsychotics reported a greater reduction in depression than patients treated with clozapine, but not when limiting the analyses to those with clinically relevant depression. Conclusions. Atypical antipsychotics may be effective in reducing psychotic and depressive symptoms and in improving insight in patients with chronic schizophrenia, with no differences in the profiles of efficacy between compounds.

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非典型抗精神病药物治疗慢性精神分裂症患者的抑郁和精神病症状:一项自然主义研究
目标。这项自然主义研究的目的是调查氯氮平和其他非典型抗精神病药物治疗至少2年是否与精神病和抑郁症状的减轻以及慢性精神分裂症患者对其疾病的认识的改善有关。方法。本研究纳入了23例接受氯氮平治疗的成人门诊患者(15男8女)和23例接受其他非典型抗精神病药物治疗的患者(16男7女)。使用阳性和阴性综合征量表(PANSS)评估精神病症状,使用卡尔加里精神分裂症抑郁量表(CDSS)评估抑郁症状,使用精神障碍无意识评估量表(SUMD)评估洞察力。结果。整个样本的阳性、阴性和一般症状都有显著减少,而抑郁的减少只有在基线时CDSS评分为5分及以上的患者才有显著减少。在随访中,接受其他非典型抗精神病药物治疗的患者比接受氯氮平治疗的患者抑郁程度更低,但当分析仅限于临床相关抑郁症患者时,情况并非如此。结论。非典型抗精神病药物可能在减轻精神病和抑郁症状以及改善慢性精神分裂症患者的洞察力方面有效,不同化合物的疗效概况没有差异。
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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