Circulating MicroRNAs as Biomarkers of Prostate Cancer: The State of Play.

IF 2.3 Q3 ONCOLOGY Prostate Cancer Pub Date : 2013-01-01 Epub Date: 2013-03-12 DOI:10.1155/2013/539680
Nikhil Sapre, Luke A Selth
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引用次数: 53

Abstract

MicroRNAs are key regulators of gene expression and play critical roles in both normal physiology and pathology. Recent research has demonstrated that these molecules are present in body fluids, such as serum, plasma, and urine, and can be readily measured using a variety of techniques. More importantly, emerging evidence suggests that circulating or urine miRNAs are useful indicators of disease. Here, we consider the potential utility of such miRNAs as noninvasive biomarkers of prostate cancer, a disease that would benefit substantially from novel diagnostic and prognostic tools. The studies aimed at identifying diagnostic, prognostic, and/or predictive miRNAs for prostate cancer are summarised and reviewed. Finally, practical considerations that will influence the translation of this recent research into clinical implementation are discussed.

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循环microrna作为前列腺癌的生物标志物:研究进展。
MicroRNAs是基因表达的关键调控因子,在正常生理和病理中都起着关键作用。最近的研究表明,这些分子存在于体液中,如血清、血浆和尿液,并且可以很容易地使用各种技术进行测量。更重要的是,新出现的证据表明,循环或尿液中的mirna是疾病的有用指标。在这里,我们考虑这些mirna作为前列腺癌的非侵入性生物标志物的潜在效用,这种疾病将从新的诊断和预后工具中获益。本文总结和回顾了旨在确定前列腺癌诊断、预后和/或预测性mirna的研究。最后,讨论了将影响这项最新研究转化为临床实施的实际考虑因素。
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来源期刊
Prostate Cancer
Prostate Cancer ONCOLOGY-
CiteScore
2.70
自引率
0.00%
发文量
9
审稿时长
13 weeks
期刊介绍: Prostate Cancer is a peer-reviewed, Open Access journal that provides a multidisciplinary platform for scientists, surgeons, oncologists and clinicians working on prostate cancer. The journal publishes original research articles, review articles, and clinical studies related to the diagnosis, surgery, radiotherapy, drug discovery and medical management of the disease.
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