Gastrin-releasing peptide as a molecular target for inflammatory diseases: an update.

Fabricia Petronilho, Lucineia Gainski Danielski, Rafael Roesler, Gilberto Schwartsmann, Felipe Dal-Pizzol
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引用次数: 27

Abstract

Gastrin-releasing peptide (GRP) is a neuropeptide that acts through G protein coupled receptors and is involved in signal transmission in both the central and peripheral nervous systems. Its receptor, gastrin-releasing peptide receptor (GRPR), is expressed by various cell types, and it is overexpressed in cancer cells. In recent years, studies have suggested the relationship of GRP and inflammatory diseases. RC-3095, a selective GRPR antagonist, was found to have antiinflammatory properties in models of arthritis, gastritis, uveitis and sepsis. Furthermore, GRP mediates air pollutioninduced airway hyperreactivity and airway inflammation in mice. In conclusion, GRP and its receptor are relevant to the inflammatory response, being a potential therapeutic target several diseases are related to inflammation.

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胃泌素释放肽作为炎症性疾病的分子靶标:最新进展。
胃泌素释放肽(Gastrin-releasing peptide, GRP)是一种通过G蛋白偶联受体起作用的神经肽,参与中枢和外周神经系统的信号传递。其受体胃泌素释放肽受体(GRPR)在多种细胞类型中均有表达,并在癌细胞中过表达。近年来有研究提出GRP与炎性疾病的关系。RC-3095是一种选择性GRPR拮抗剂,在关节炎、胃炎、葡萄膜炎和败血症模型中具有抗炎作用。此外,GRP介导空气污染诱导的小鼠气道高反应性和气道炎症。综上所述,GRP及其受体与炎症反应有关,是几种与炎症相关疾病的潜在治疗靶点。
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