Butyl methoxy dibenzoylmethane.

Q1 Pharmacology, Toxicology and Pharmaceutics Profiles of drug substances, excipients, and related methodology Pub Date : 2013-01-01 DOI:10.1016/B978-0-12-407691-4.00003-4

Jutta Kockler, Sherryl Robertson, Michael Oelgemöller, Murray Davies, Bruce Bowden, Harry G Brittain, Beverley D Glass

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引用次数: 15

Abstract

A comprehensive profile on Butyl methoxy dibenzoylmethane, one of the most commonly used ultraviolet (UV) filters in topical sunscreen products, is prepared. This UV filter, often referred to as Avobenzone, has its main absorbance in the UVA I region of the spectrum and is susceptible to photodegradation. The profile contains the following sections: general information, use and mechanism of action, method of preparation, physical characteristics, methods of analysis, stability, and toxicity. The physical characteristics section includes the melting range, differential scanning calorimetry, partition coefficient, ionization constant, solubility, and UV, infrared, nuclear magnetic resonance ((1)H NMR and (13)C NMR) and mass spectrometry and X-ray powder diffractometry. The method of analysis section in addition to compendial identification and purity and assay methods includes thin-layer gas and high-performance liquid chromatography. The photostability and photostabilization of Butyl methoxy dibenzoylmethane, in addition to its toxicity, are also documented.

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丁基甲氧基二苯甲酰甲烷。

全面介绍了丁基甲氧基二苯甲酰甲烷，它是局部防晒产品中最常用的紫外线过滤器之一。这种紫外线滤光剂，通常被称为阿伏苯宗，其主要吸收光谱的UVA I区域，易受光降解。说明书包含以下部分:一般信息、用途和作用机制、制备方法、物理特性、分析方法、稳定性和毒性。物理特征部分包括熔融范围、差示扫描量热、分配系数、电离常数、溶解度，以及紫外、红外、核磁共振((1)H NMR和(13)C NMR)、质谱和x射线粉末衍射。分析方法除药典鉴定和纯度测定方法外，还包括薄层气相色谱法和高效液相色谱法。除了其毒性外，丁基甲氧基二苯甲酰甲烷的光稳定性和光稳定性也被记录下来。

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