Brain areas and pathways in the regulation of glucose metabolism.

IF 5 3区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY BioFactors Pub Date : 2013-09-01 Epub Date: 2013-08-01 DOI:10.1002/biof.1123

Charlene Diepenbroek, Mireille J Serlie, Eric Fliers, Andries Kalsbeek, Susanne E la Fleur

引用次数: 15

Abstract

Glucose is the most important source of fuel for the brain and its concentration must be kept within strict boundaries to ensure the organism's optimal fitness. To maintain glucose homeostasis, an optimal balance between glucose uptake and glucose output is required. Besides managing acute changes in plasma glucose concentrations, the brain controls a daily rhythm in glucose concentrations. The various nuclei within the hypothalamus that are involved in the control of both these processes are well known. However, novel studies indicate an additional role for brain areas that are originally appreciated in other processes than glucose metabolism. Therefore, besides the classic hypothalamic pathways, we will review cortico-limbic brain areas and their role in glucose metabolism.

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调节葡萄糖代谢的脑区和通路。

葡萄糖是大脑最重要的燃料来源，它的浓度必须保持在严格的范围内，以确保生物体的最佳适应性。为了维持葡萄糖稳态，需要葡萄糖摄取和葡萄糖输出之间的最佳平衡。除了管理血浆葡萄糖浓度的急性变化外，大脑还控制葡萄糖浓度的日常节律。下丘脑内参与控制这两个过程的各种核是众所周知的。然而，新的研究表明，大脑区域最初在葡萄糖代谢之外的其他过程中发挥着额外的作用。因此，除了经典的下丘脑通路外，我们将回顾皮质边缘脑区及其在葡萄糖代谢中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BioFactors 生物-内分泌学与代谢

CiteScore

11.50

自引率

3.30%

发文量

审稿时长

6-12 weeks

期刊介绍： BioFactors, a journal of the International Union of Biochemistry and Molecular Biology, is devoted to the rapid publication of highly significant original research articles and reviews in experimental biology in health and disease. The word “biofactors” refers to the many compounds that regulate biological functions. Biological factors comprise many molecules produced or modified by living organisms, and present in many essential systems like the blood, the nervous or immunological systems. A non-exhaustive list of biological factors includes neurotransmitters, cytokines, chemokines, hormones, coagulation factors, transcription factors, signaling molecules, receptor ligands and many more. In the group of biofactors we can accommodate several classical molecules not synthetized in the body such as vitamins, micronutrients or essential trace elements. In keeping with this unified view of biochemistry, BioFactors publishes research dealing with the identification of new substances and the elucidation of their functions at the biophysical, biochemical, cellular and human level as well as studies revealing novel functions of already known biofactors. The journal encourages the submission of studies that use biochemistry, biophysics, cell and molecular biology and/or cell signaling approaches.