Heparin and related drugs: beyond anticoagulant activity.

ISRN Pharmacology Pub Date : 2013-07-30 eCollection Date: 2013-01-01 DOI:10.1155/2013/910743
Clive Page
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Abstract

Heparin has been widely used as an anticoagulant for more than 80 years. However, there is now considerable evidence that heparin also possesses anti-inflammatory activity, both experimentally and clinically. Importantly in many instances, the anti-inflammatory actions of heparin are independent of anticoagulant activity raising the possibility of developing novel drugs based on heparin that retain the anti-inflammatory activity. Heparin exhibits anti-inflammatory activities via a variety of mechanisms including neutralization of cationic mediators, inhibition of adhesion molecules, and the inhibition of heparanase, all involved in leukocyte recruitment into tissues. It is anticipated that furthering our understanding of the anti-inflammatory actions of heparin will lead to the development of novel anti-inflammatory drugs for a variety of clinical indications.

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肝素及相关药物:超越抗凝活性。
80 多年来,肝素一直被广泛用作抗凝剂。然而,现在有大量证据表明,肝素在实验和临床上也具有抗炎活性。重要的是,在许多情况下,肝素的抗炎作用与抗凝活性无关,这就为基于肝素开发保留抗炎活性的新型药物提供了可能性。肝素通过多种机制表现出抗炎作用,包括中和阳离子介质、抑制粘附分子和抑制肝素酶,这些机制都参与了白细胞向组织的募集。随着我们对肝素抗炎作用的进一步了解,有望开发出适用于各种临床适应症的新型抗炎药物。
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