A simple, efficient synthesis of 2-aryl benzimidazoles using silica supported periodic Acid catalyst and evaluation of anticancer activity.

ISRN Organic Chemistry Pub Date : 2013-04-24 eCollection Date: 2013-01-01 DOI:10.1155/2013/453682
Vyankat A Sontakke, Sougata Ghosh, Pravin P Lawande, Balu A Chopade, Vaishali S Shinde
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引用次数: 27

Abstract

A new, efficient method for the synthesis of 2-aryl substituted benzimidazole by using silica supported periodic acid (H5IO6-SiO2) as a catalyst has been developed. The salient feature of the present method includes mild reaction condition, short reaction time, high yield and easy workup procedure. The synthesized benzimidazoles exhibited potent anticancer activity against MCF7 and HL60 cell lines.

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二氧化硅负载周期酸催化剂合成2-芳基苯并咪唑及其抗癌活性评价。
研究了以二氧化硅负载的周期酸(H5IO6-SiO2)为催化剂合成2-芳基取代苯并咪唑的新方法。该方法具有反应条件温和、反应时间短、收率高、后处理方便等特点。所合成的苯并咪唑对MCF7和HL60细胞株具有较强的抗癌活性。
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