Thio Analogs of Pyrimidine Bases: Synthesis, Spectroscopic Study, and In Silico Biological Activity Evaluation of New 2-o-(m- and p-)Chlorobenzylthio-6-Methyl-5-Piperidino-(Morpholino-)Methyluracils.

ISRN Organic Chemistry Pub Date : 2011-04-07 eCollection Date: 2011-01-01 DOI:10.5402/2011/610521
Tomasz Pospieszny, Marcin Szymankiewicz, Elżbieta Wyrzykiewicz
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引用次数: 2

Abstract

Six new 2-o-(m- and p-)chlorobenzylthio-6-methyl-5-piperidino-(or morpholino-) methyluracils have been prepared. The structures of these compounds were confirmed by spectroscopic (FT-IR, UV-Vis, 1H NMR, 13C NMR, and HMBC) and elemental analyses. Estimation of pharmacotherapeutic potential has been made for synthesized compounds on the basis of prediction of activity spectra for substances (PASS).

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嘧啶基硫代类似物:新的2-o-(m-和对-)氯苯基硫-6-甲基-5-哌替啶-(Morpholino-)甲基尿嘧啶的合成、光谱研究和硅生物活性评价。
合成了6个新的2-o-(m-和对-)氯苯基硫-6-甲基-5-哌替啶-(或morpholino-)甲基尿嘧啶。通过光谱(FT-IR, UV-Vis, (1)H NMR, (13)C NMR和HMBC)和元素分析证实了这些化合物的结构。在物质活性谱预测(PASS)的基础上,对合成的化合物进行了药物治疗潜力的估计。
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