A Green, Expeditious, One-Pot Synthesis of 3, 4-Dihydropyrimidin-2(1H)-ones Using a Mixture of Phosphorus Pentoxide-Methanesulfonic Acid at Ambient Temperature.

ISRN Organic Chemistry Pub Date : 2012-08-08 eCollection Date: 2012-01-01 DOI:10.5402/2012/415645
Amulrao Borse, Mahesh Patil, Nilesh Patil, Rohan Shinde
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引用次数: 8

Abstract

An expeditious, one-pot method for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones using a mixture of phosphorus pentoxide-methanesulfonic acid (Eaton's reagent) at room temperature under solvent-free conditions is described. The salient features of this method include short reaction time, green aspects, high yields, and simple procedure.

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室温下以五氧化二磷-甲磺酸为原料一锅绿色快速合成3,4 -二氢嘧啶-2(1H)- 1。
介绍了以五氧化二磷-甲磺酸(伊顿试剂)为原料,在室温无溶剂条件下一锅快速合成3,4-二氢嘧啶-2(1H)- 1的方法。该方法具有反应时间短、绿色环保、收率高、操作简单等特点。
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