Serum interleukin-6 expression level and its clinical significance in patients with dermatomyositis.

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-09-03 DOI:10.1155/2013/717808

Min Yang, Xiaomin Cen, Qibing Xie, Chuan Zuo, Guixiu Shi, Geng Yin

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引用次数: 21

Abstract

Objective: To analyze serum interleukin-6 (IL-6) expression level and its clinical significance in patients with dermatomyositis.

Methods: Blood samples from 23 adult patients with dermatomyositis (DM), 22 with systemic lupus erythematosus (SLE), 22 with rheumatoid arthritis (RA), 16 with Sjögren's syndrome (SS), and 20 healthy controls were collected. The IL-6 concentration was detected by chemiluminescence immunoassay. Correlations between IL-6 expression levels and clinical features or laboratory findings in patients with DM were investigated.

Results: IL-6 expression level of DM patients was significantly higher than that of normal controls, significantly lower than that of RA patients, and slightly lower than that of SLE or SS patients with no significant differences. The incidence of fever was significantly higher in the IL-6 elevated group. Serum ferritin (SF) and C-reactive protein (CRP) were positively correlated with IL-6.

Conclusions: IL-6 plays a less important role in DM than in RA. IL-6 monoclonal antibodies may have poor effect in patients with DM.

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皮肌炎患者血清白细胞介素-6表达水平及临床意义

目的:分析皮肌炎患者血清白细胞介素-6 (IL-6)表达水平及其临床意义。方法:采集成人皮肌炎(DM)患者23例，系统性红斑狼疮(SLE)患者22例，类风湿性关节炎(RA)患者22例，Sjögren综合征(SS)患者16例，健康对照20例。化学发光免疫法检测IL-6浓度。探讨IL-6表达水平与糖尿病患者临床特征或实验室结果的相关性。结果:IL-6在DM患者中的表达水平显著高于正常对照组，显著低于RA患者，略低于SLE和SS患者，差异无统计学意义。IL-6升高组发热发生率明显增高。血清铁蛋白(SF)和c反应蛋白(CRP)与IL-6呈正相关。结论:IL-6在DM中的作用小于RA。IL-6单克隆抗体对糖尿病患者可能效果较差。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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