Isolation, pharmacological activity and structure determination of physalin B and 5β,6β-epoxyphysalin B isolated from Congolese Physalis angulata L.

IF 0.8 4区化学 Acta crystallographica. Section C, Crystal structure communications Pub Date : 2013-12-15 Epub Date: 2013-11-30 DOI:10.1107/S010827011303117X

Peter Mangwala Kimpende, Mariano Lusakibanza, Kahunu Mesia, Lutete Tona, Monique Tits, Luc Angenot, Michel Frédérich, Luc Van Meervelt

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引用次数: 14

Abstract

Physalis angulata L., an annual herb from the Solanaceae family, is widely used in popular medicine in tropical countries to treat a variety of diseases. Two products, (X) and (Y), were isolated from a crude CH2Cl2 extract of dried Congolese Physalis angulata L. plants and crystallized from acetone for structure elucidation. Compound (X) corresponds to a physalin B dimer acetone solvate hydrate (2C28H30O9·C3H6O·0.22H2O), while compound (Y) crystallizes as a mixed crystal containing two physalin B molecules which overlap with 5β,6β-epoxyphysalin B, also known as physalin F, and one acetone molecule in the asymmetric unit (1.332C28H30O9·0.668C28H30O10·C3H6O). Antiplasmodial activity, cytotoxic activity and selectivity indices were determined for crude extracts and the two isolated products (X) and (Y).

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刚果角Physalis physalin B和5β，6β-环氧physalin B的分离、药理活性和结构测定。

角Physalis angulata L.是一种茄科一年生草本植物，在热带国家的流行医学中被广泛用于治疗多种疾病。两个产物(X)和(Y)是从干燥的刚果角Physalis l.l .植物的粗CH2Cl2提取物中分离出来的，并从丙酮中结晶以进行结构鉴定。化合物(X)对应于一个二聚丙酮溶剂化物水合物(2C28H30O9·c3h60·0.22H2O)，而化合物(Y)结晶为一个混合晶体，包含两个physalin B分子，它们与5β，6β-环氧physalin B(也称为physalin F)和一个不对称单元的丙酮分子(1.332C28H30O9·0.668C28H30O10·c3h60)重叠。测定粗提物和分离产物(X)、(Y)的抗疟原虫活性、细胞毒活性和选择性指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Acta crystallographica. Section C, Crystal structure communications 化学-晶体学

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12.50%

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1 months

期刊介绍： Acta Crystallographica Section C: Structural Chemistry is continuing its transition to a journal that publishes exciting science with structural content, in particular, important results relating to the chemical sciences. Section C is the journal of choice for the rapid publication of articles that highlight interesting research facilitated by the determination, calculation or analysis of structures of any type, other than macromolecular structures. Articles that emphasize the science and the outcomes that were enabled by the study are particularly welcomed. Authors are encouraged to include mainstream science in their papers, thereby producing manuscripts that are substantial scientific well-rounded contributions that appeal to a broad community of readers and increase the profile of the authors.

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