Benign pairs: a significant entity in aspiration cytology smears from breast lesions.

Q3 Medicine Clinical Medicine Insights- Pathology Pub Date : 2013-11-28 eCollection Date: 2013-01-01 DOI:10.4137/CPath.S13273

Monika Rathi, Pooja Kala, Atul Gupta, Satish Kumar Budania, Harshkiran Ahuja

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Abstract

Introduction: Fine needle aspiration cytology (FNAC) is a reliable diagnostic tool used to diagnose breast lesions preoperatively. However, FNAC is also associated with diagnostic pitfalls. Further studies are needed to improve its diagnostic efficacy. We noticed ovoid, bare nuclei arranged in closely touching diads (benign pairs) in a significant number of cytology smears. This prompted us to assess their diagnostic utility.

Materials and methods: This was a prospective study conducted in Sarojini NaiduMedical College, Agra, India. Quantitative estimation of benign pairs per 1000 ductal cells in at least 20 high power field was attempted in cytology smears of 128 cases.

Results: The average number of pairs in benign and malignant lesions was calculated as 7.07 + 5.96 and 0.28 + 0.78, respectively. Statistical analysis showed a significant difference between the number of pairs in benign and malignant cases (P < 0.0005).

Conclusions: Quantitative estimation of benign pairs is helpful in distinguishing benign from malignant cases.

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良性对:乳腺病变吸吸细胞学涂片的重要组成部分。

细针吸细胞学(FNAC)是一种可靠的诊断工具，用于术前诊断乳腺病变。然而，FNAC也与诊断缺陷有关。需进一步研究以提高其诊断效能。在大量细胞学涂片中，我们注意到卵形、裸露的细胞核排列在紧密接触的二极体中(良性对)。这促使我们评估它们的诊断效用。材料和方法:这是一项在印度阿格拉Sarojini NaiduMedical College进行的前瞻性研究。对128例患者的细胞学涂片进行了至少20次高倍视野下每1000个导管细胞中良性对的定量估计。结果:良、恶性病变的平均配对数分别为7.07 + 5.96和0.28 + 0.78。经统计学分析，良、恶性病例配对数差异有统计学意义(P < 0.0005)。结论:定量估计良性对有助于区分良恶性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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