Toxicity biomarkers among US children compared to a similar cohort in France: a blinded study measuring urinary porphyrins.

IF 1.1 4区环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES Toxicological and Environmental Chemistry Pub Date : 2011-02-01 Epub Date: 2010-08-12 DOI:10.1080/02772248.2010.508609

Janet K Kern, David A Geier, Françoise Ayzac, James B Adams, Jyutika A Mehta, Mark R Geier

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Abstract

The purpose of this blinded study was to evaluate potential environmental toxicity in a cohort of neurotypical children (n = 28) living in a suburban area of north-central Texas in the United States (US) with a comparable age- and gender-matched cohort of neurotypical children (n = 28) living in a suburban area of southeastern France using urinary porphyrin testing: uroporphyrin (uP), heptacarboxyporphyrin (7cxP), hexacarboxyporphyrin (6cxP), pentacarboxyporphyrin (5cxP), precoproporphyrin (prcP), and coproporphyrin (cP). Results showed significantly elevated 6cxP, prcP (an atypical, mercury-specific porphyrin), and cP levels, and increasing trends in 5cxP levels, among neurotypical children in the USA compared to children in France. Data suggest that in US neurotypical children, there is a significantly increased body-burden of mercury (Hg) compared to the body-burden of Hg in the matched neurotypical children in France. The presence of lead contributing to the higher levels of cP also needs to be considered. Further, other factors including genetics can not be completely ruled out.

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美国儿童与法国类似人群的毒性生物标志物比较：一项测量尿卟啉的盲法研究。

这项盲法研究的目的是通过尿卟啉检测，评估居住在美国得克萨斯州中北部郊区的一组神经畸形儿童（n = 28）与居住在法国东南部郊区的一组年龄和性别相当的神经畸形儿童（n = 28）的潜在环境毒性：尿卟啉 (uP)、七羧基卟啉 (7cxP)、六羧基卟啉 (6cxP)、五羧基卟啉 (5cxP)、前卟啉 (prcP) 和共卟啉 (cP)。结果显示，与法国儿童相比，美国神经畸形儿童的 6cxP、prcP（一种非典型汞特异性卟啉）和 cP 水平明显升高，5cxP 水平呈上升趋势。数据表明，与法国神经畸形儿童的体内汞负担相比，美国神经畸形儿童的体内汞负担明显增加。此外，还需要考虑导致 cP 水平升高的铅的存在。此外，还不能完全排除包括遗传在内的其他因素。

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来源期刊

Toxicological and Environmental Chemistry ENVIRONMENTAL SCIENCES-TOXICOLOGY

CiteScore

3.50

自引率

5.60%

发文量

期刊介绍： The journal is interdisciplinary in outlook, and manuscripts published in it cover all relevant areas: • inorganic chemistry – trace elements in food and the environment, metal complexes and chelates; • organic chemistry – environmental fate, chemical reactions, metabolites and secondary products, synthesis of standards and labelled materials; • physical chemistry – photochemistry, radiochemistry; • environmental chemistry – sources, fate, and sinks of xenochemicals, environmental partitioning and transport, degradation and deposition; • analytical chemistry – development and optimisation of analytical methods, instrumental and methodological advances, miniaturisation and automation; • biological chemistry – pharmacology and toxicology, uptake, metabolism, disposition of xenochemicals, structure-activity relationships, modes of action, ecotoxicological testing.