Primary Zonal High Intensity Focused Ultrasound for Prostate Cancer: Results of a Prospective Phase IIa Feasibility Study.

IF 2.3 Q3 ONCOLOGY Prostate Cancer Pub Date : 2014-01-01 Epub Date: 2014-01-23 DOI:10.1155/2014/756189
Roland Van Velthoven, Fouad Aoun, Ksenija Limani, Krishna Narahari, Marc Lemort, Alexandre Peltier
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引用次数: 0

Abstract

Objectives: To present the results of a prospective phase IIa study assessing the role of primary zonal High Intensity Focused Ultrasound (HIFU) for prostate cancer treatment.

Methods: 31 consecutive patients with unilateral organ confined prostate cancer primarily treated by zonal HIFU (from February 2007 to June 2011) were recruited into a single centre prospective phase IIa feasibility study. Complications were prospectively recorded and graded according to the Clavien-Dindo score. Postoperatively, patients were followed with serial serum PSA determinations and digital rectal examinations. An individual PSA nadir was identified in each patient. Followup also included whole gland biopsies performed in the event of a PSA rising>2.0 ng/mL above nadir value (Phoenix criteria).

Results: At a median followup of 38 months, biochemical recurrence free survival was 100%, 89%, and 82.7% at 1, 2, and 3 years, respectively, with overall and cancer specific survival of 100%. The procedure was safe and well tolerated with no major adverse events. All patients were continent at their last followup and 55.2% (16/29) had erectile function sufficient for penetration.

Conclusion: Primary zonal HIFU is a valid focal therapy strategy, safe and feasible in day to day practice with good promising results [corrected].

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治疗前列腺癌的原发区域高强度聚焦超声:前瞻性 IIa 期可行性研究结果。
研究目的方法:31例单侧器官局限性前列腺癌患者(2007年2月至2011年6月)被纳入单中心前瞻性IIa期可行性研究。前瞻性记录并根据克拉维恩-丁多评分对并发症进行分级。术后对患者进行系列血清 PSA 测定和数字直肠检查。每位患者的 PSA 最低值都已确定。随访还包括在 PSA 升高超过阈值 2.0 纳克/毫升时进行全腺活检(凤凰标准):中位随访时间为 38 个月,1 年、2 年和 3 年的无生化复发生存率分别为 100%、89% 和 82.7%,总生存率和癌症特异性生存率均为 100%。手术安全且耐受性良好,无重大不良反应。所有患者在最后一次随访时均为阴茎持续勃起,55.2%(16/29)的患者勃起功能足以插入阴茎:原发分区 HIFU 是一种有效的病灶治疗策略,在日常实践中安全可行,效果良好[已更正]。
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来源期刊
Prostate Cancer
Prostate Cancer ONCOLOGY-
CiteScore
2.70
自引率
0.00%
发文量
9
审稿时长
13 weeks
期刊介绍: Prostate Cancer is a peer-reviewed, Open Access journal that provides a multidisciplinary platform for scientists, surgeons, oncologists and clinicians working on prostate cancer. The journal publishes original research articles, review articles, and clinical studies related to the diagnosis, surgery, radiotherapy, drug discovery and medical management of the disease.
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