Vascular endothelial growth factor and brain-derived neurotrophic factor in quetiapine treated first-episode psychosis.

IF 3.6 Q1 PSYCHIATRY Schizophrenia Research and Treatment Pub Date : 2014-01-01 Epub Date: 2014-02-05 DOI:10.1155/2014/719395
Brendan P Murphy, Terence Y Pang, Anthony J Hannan, Tina-Marie Proffitt, Mirabel McConchie, Melissa Kerr, Connie Markulev, Colin O'Donnell, Patrick D McGorry, Gregor E Berger
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引用次数: 27

Abstract

Objective. It has been suggested that atypical antipsychotics confer their effects via brain-derived neurotrophic factor (BDNF). We investigated the effect of quetiapine on serum levels of BDNF and vascular endothelial growth factor (VEGF) in drug-naive first-episode psychosis subjects. Methods. Fifteen patients drawn from a larger study received quetiapine treatment for twelve weeks. Baseline levels of serum BDNF and VEGF were compared to age- and sex-matched healthy controls and to levels following treatment. Linear regression analyses were performed to determine the relationship of BDNF and VEGF levels with outcome measures at baseline and week 12. Results. The mean serum BDNF level was significantly higher at week 12 compared to baseline and correlated with reductions in Brief Psychiatric Rating Scale (BPRS) and general psychopathology scores. Changes in serum VEGF levels also correlated significantly with a reduction in BPRS scores, a significant improvement in PANNS positive symptoms scores, and displayed a positive relationship with changes in BDNF levels. Conclusions. Our findings suggest that BDNF and VEGF are potential biomarkers for gauging improvement of psychotic symptoms. This suggests a novel neurotrophic-based mechanism of the drug effects of quetiapine on psychosis. This is the first report of VEGF perturbation in psychosis.

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血管内皮生长因子和脑源性神经营养因子在奎硫平治疗首发精神病中的作用。
目标。有研究表明,非典型抗精神病药物通过脑源性神经营养因子(BDNF)发挥作用。我们研究了喹硫平对未用药首发精神病患者血清BDNF和血管内皮生长因子(VEGF)水平的影响。方法。从一项更大的研究中抽取的15名患者接受了为期12周的喹硫平治疗。将血清BDNF和VEGF的基线水平与年龄和性别匹配的健康对照组以及治疗后的水平进行比较。进行线性回归分析以确定基线和第12周时BDNF和VEGF水平与结果测量的关系。结果。在第12周,与基线相比,平均血清BDNF水平显著升高,并与简短精神病学评定量表(BPRS)和一般精神病理学评分的降低相关。血清VEGF水平的变化还与BPRS评分的降低、PANNS阳性症状评分的显著改善显著相关,并与BDNF水平的变化呈正相关。结论。我们的研究结果表明BDNF和VEGF是衡量精神病症状改善的潜在生物标志物。这表明喹硫平对精神病的药物作用是一种新的神经营养机制。这是第一个关于精神疾病中VEGF紊乱的报道。
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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