[Human immunodeficiency virus type 1 subtypes in Djibouti].

A Elmi Abar, A Jlizi, H Youssouf Darar, M Ben Nasr, S Abid, M Ali Ben Hadj Kacem, A Slim
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Abstract

The authors had for aim to study the distribution of HIV-1 subtypes in a cohort of HIV positive patients in the hospital General Peltier of Djibouti. An epidemiological study was made on 40 HIV-1 positive patients followed up in the Infectious Diseases Department over three months. All patients sample were subtyped by genotyping. Thirty-five patients (15 men and 20 women) were found infected by an HIV-1 strain belonging to the M group. Genotyping revealed that - 66% of samples were infected with subtype C, 20% with CRF02_AG, 8.5% with B, 2.9% with CRF02_AG/C and 2.9% with K/C. In fact, Subtype C prevalence has been described in the Horn of Africa and a similar prevalence was previously reported in Djibouti. However our study describes the subtype B in Djibouti for the first time. It is the predominant subtype in the Western world. The detection of CRF02_AG strains indicates that they are still circulating in Djibouti, the only country in East Africa in which this recombinant virus was found. CRF02_AG recombinant isolates were primarily described in West and Central Africa. The presence of this viral heterogeneity, probably coming from the mixing of populations in Djibouti, which is an essential economic and geographical crossroads, incites us to vigilance in the surveillance of this infection.

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[吉布提人类免疫缺陷病毒1型亚型]。
作者的目的是研究HIV-1亚型在吉布提Peltier医院HIV阳性患者队列中的分布。对在传染病科随访3个月的40例HIV-1阳性患者进行了流行病学研究。所有患者样本均进行基因分型。35名患者(15名男性和20名女性)被发现感染了属于M组的HIV-1毒株。基因分型结果显示,- 66%的样本感染C亚型,20%感染CRF02_AG亚型,8.5%感染B亚型,2.9%感染CRF02_AG/C亚型,2.9%感染K/C亚型。事实上,在非洲之角已经描述了C亚型的流行情况,以前在吉布提报告了类似的流行情况。然而,我们的研究首次在吉布提描述了B亚型。它是西方世界的主要亚型。CRF02_AG毒株的检测表明,它们仍在吉布提流行,吉布提是东非唯一发现这种重组病毒的国家。CRF02_AG重组分离株主要在西非和中非被发现。这种病毒异质性的存在,可能来自吉布提人口的混合,吉布提是一个重要的经济和地理十字路口,这促使我们在监测这种感染时保持警惕。
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