Aging of the brain, dementias, role of infectious proteins: facts and theories.

Interdisciplinary topics in gerontology Pub Date : 2014-01-01 Epub Date: 2014-05-13 DOI:10.1159/000358905
Frédéric Morinet
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引用次数: 1

Abstract

Neurodegenerative diseases, including Alzheimer's, Parkinson's and prion diseases are a major and growing public health issue for aging populations as aging is the greatest risk factor for neurodegeneration. Protein misfolding and spreading are common to these neurodegenerative diseases. There are many high-quality reviews concerning these diseases; also in this brief chapter, I have tried to give a summary of the principal points involved in the pathogenesis of these three clinical entities.
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脑老化,痴呆,感染性蛋白的作用:事实和理论。
神经退行性疾病,包括阿尔茨海默病、帕金森病和朊病毒病,是老龄化人口日益严重的主要公共卫生问题,因为老龄化是神经退行性疾病的最大危险因素。蛋白质错误折叠和扩散在这些神经退行性疾病中是常见的。关于这些疾病有许多高质量的综述;在这简短的一章中,我也试图对这三个临床实体的发病机制所涉及的要点进行总结。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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Introduction to the theory of aging networks. Applications to aging networks. Computational systems biology for aging research. How does the body know how old it is? Introducing the epigenetic clock hypothesis. The great evolutionary divide: two genomic systems biologies of aging.
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