In vivo ciprofloxacin release from hydroxyapatite-based bone implants in rabbit tibia: a preliminary study.

ISRN orthopedics Pub Date : 2011-12-07 eCollection Date: 2011-01-01 DOI:10.5402/2011/420549

Amit Kumar Nayak, Ajoy Bhattacharyya, Kalyan Kumar Sen

{"title":"In vivo ciprofloxacin release from hydroxyapatite-based bone implants in rabbit tibia: a preliminary study.","authors":"Amit Kumar Nayak, Ajoy Bhattacharyya, Kalyan Kumar Sen","doi":"10.5402/2011/420549","DOIUrl":null,"url":null,"abstract":"<p><p>The present study deals with the preliminary evaluation of in vivo ciprofloxacin release from HAp-ciprofloxacin bone implants in rabbit tibia. The HAp-ciprofloxacin implants (2 × 2.5 mm) were prepared using various HAp-ciprofloxacin composites synthesized by precipitation technique and 1.5% w/v guar gum as a binder. 5 implants were implanted in artificial cortical bone window at the right proximal tibia of each rabbit. After 3- and 6-day intervals, the rabbits were euthanized. Bone marrow and serum concentrations of ciprofloxacin were determined from the harvested tibia using HPLC method. The results displayed the availability of elevated local antibiotic concentration at the implanted site with the limitation of systemic antibiotic exposure, which can be useful to minimize the risk of systemic toxicity-related side effects. This study is the preliminary investigation of the suitability of in vivo ciprofloxacin release from HAp-ciprofloxacin bone implants in rabbit tibia, after implantation, and these implants can be useful for the treatment of bacterial bone infections like osteomyelitis. </p>","PeriodicalId":89787,"journal":{"name":"ISRN orthopedics","volume":"2011 ","pages":"420549"},"PeriodicalIF":0.0000,"publicationDate":"2011-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063217/pdf/","citationCount":"22","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ISRN orthopedics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5402/2011/420549","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2011/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 22

Abstract

The present study deals with the preliminary evaluation of in vivo ciprofloxacin release from HAp-ciprofloxacin bone implants in rabbit tibia. The HAp-ciprofloxacin implants (2 × 2.5 mm) were prepared using various HAp-ciprofloxacin composites synthesized by precipitation technique and 1.5% w/v guar gum as a binder. 5 implants were implanted in artificial cortical bone window at the right proximal tibia of each rabbit. After 3- and 6-day intervals, the rabbits were euthanized. Bone marrow and serum concentrations of ciprofloxacin were determined from the harvested tibia using HPLC method. The results displayed the availability of elevated local antibiotic concentration at the implanted site with the limitation of systemic antibiotic exposure, which can be useful to minimize the risk of systemic toxicity-related side effects. This study is the preliminary investigation of the suitability of in vivo ciprofloxacin release from HAp-ciprofloxacin bone implants in rabbit tibia, after implantation, and these implants can be useful for the treatment of bacterial bone infections like osteomyelitis.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

羟基磷灰石骨植入物在兔胫骨体内释放环丙沙星的初步研究。

本研究对hap -环丙沙星骨植入物在兔胫骨体内释放环丙沙星进行了初步评价。采用沉淀法合成各种hap -环丙沙星复合材料，以1.5% w/v瓜尔胶为粘结剂，制备hap -环丙沙星种植体(2 × 2.5 mm)。在每只兔右侧胫骨近端人工皮质骨窗内植入5个假体。间隔3天和6天后，对家兔实施安乐死。采用高效液相色谱法测定采集胫骨骨髓和血清环丙沙星浓度。结果显示，植入部位局部抗生素浓度升高的有效性与全身性抗生素暴露的限制，这可能有助于减少全身毒性相关副作用的风险。本研究是对hap -环丙沙星植入兔胫骨后体内释放环丙沙星的适宜性进行初步探讨，该植入物可用于骨髓炎等细菌性骨感染的治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

ISRN orthopedics

自引率

0.00%

发文量