Acid-base balance in uremic rats with vascular calcification.

Nephron Extra Pub Date : 2014-07-02 eCollection Date: 2014-01-01 DOI:10.1159/000363298

Alan Peralta-Ramírez, Ana Isabel Raya, Carmen Pineda, Mariano Rodríguez, Escolástico Aguilera-Tejero, Ignacio López

{"title":"Acid-base balance in uremic rats with vascular calcification.","authors":"Alan Peralta-Ramírez, Ana Isabel Raya, Carmen Pineda, Mariano Rodríguez, Escolástico Aguilera-Tejero, Ignacio López","doi":"10.1159/000363298","DOIUrl":null,"url":null,"abstract":"Background/aims: Vascular calcification (VC), a major complication in humans and animals with chronic kidney disease (CKD), is influenced by changes in acid-base balance. The purpose of this study was to describe the acid-base balance in uremic rats with VC and to correlate the parameters that define acid-base equilibrium with VC.Methods: Twenty-two rats with CKD induced by 5/6 nephrectomy (5/6 Nx) and 10 nonuremic control rats were studied.Results: The 5/6 Nx rats showed extensive VC as evidenced by a high aortic calcium (9.2 ± 1.7 mg/g of tissue) and phosphorus (20.6 ± 4.9 mg/g of tissue) content. Uremic rats had an increased pH level (7.57 ± 0.03) as a consequence of both respiratory (PaCO2 = 28.4 ± 2.1 mm Hg) and, to a lesser degree, metabolic (base excess = 4.1 ± 1 mmol/l) derangements. A high positive correlation between both anion gap (AG) and strong ion difference (SID) with aortic calcium (AG: r = 0.604, p = 0.02; SID: r = 0.647, p = 0.01) and with aortic phosphorus (AG: r = 0.684, p = 0.007; SID: r = 0.785, p = 0.01) was detected.Conclusions: In an experimental model of uremic rats, VC showed high positive correlation with AG and SID.","PeriodicalId":56356,"journal":{"name":"Nephron Extra","volume":"4 2","pages":"89-94"},"PeriodicalIF":0.0000,"publicationDate":"2014-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000363298","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nephron Extra","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000363298","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2014/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 4

Abstract

Background/aims: Vascular calcification (VC), a major complication in humans and animals with chronic kidney disease (CKD), is influenced by changes in acid-base balance. The purpose of this study was to describe the acid-base balance in uremic rats with VC and to correlate the parameters that define acid-base equilibrium with VC.

Methods: Twenty-two rats with CKD induced by 5/6 nephrectomy (5/6 Nx) and 10 nonuremic control rats were studied.

Results: The 5/6 Nx rats showed extensive VC as evidenced by a high aortic calcium (9.2 ± 1.7 mg/g of tissue) and phosphorus (20.6 ± 4.9 mg/g of tissue) content. Uremic rats had an increased pH level (7.57 ± 0.03) as a consequence of both respiratory (PaCO2 = 28.4 ± 2.1 mm Hg) and, to a lesser degree, metabolic (base excess = 4.1 ± 1 mmol/l) derangements. A high positive correlation between both anion gap (AG) and strong ion difference (SID) with aortic calcium (AG: r = 0.604, p = 0.02; SID: r = 0.647, p = 0.01) and with aortic phosphorus (AG: r = 0.684, p = 0.007; SID: r = 0.785, p = 0.01) was detected.

Conclusions: In an experimental model of uremic rats, VC showed high positive correlation with AG and SID.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

血管钙化尿毒症大鼠的酸碱平衡。

背景/目的:血管钙化(VC)是人类和动物慢性肾脏疾病(CKD)的主要并发症，受酸碱平衡变化的影响。本研究的目的是描述患有VC的尿毒症大鼠的酸碱平衡，并将定义酸碱平衡的参数与VC相关联。方法:以5/6肾切除术(5/6 Nx)致CKD大鼠22只和非尿毒症对照组10只为研究对象。结果:5/6 Nx大鼠主动脉钙(9.2±1.7 mg/g组织)和磷(20.6±4.9 mg/g组织)含量高，VC分布广泛。由于呼吸(PaCO2 = 28.4±2.1 mm Hg)和代谢(碱过量= 4.1±1 mmol/l)紊乱，尿毒症大鼠的pH值升高(7.57±0.03)。阴离子间隙(AG)和强离子差(SID)与主动脉钙呈高度正相关(AG: r = 0.604, p = 0.02;SID: r = 0.647, p = 0.01)与主动脉磷(AG: r = 0.684, p = 0.007;SID: r = 0.785, p = 0.01)。结论:在尿毒症大鼠实验模型中，VC与AG、SID呈高度正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Nephron Extra

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： An open-access subjournal to Nephron. ''Nephron EXTRA'' publishes additional high-quality articles that cannot be published in the main journal ''Nephron'' due to space limitations.