Exploratory meta-analysis on deep brain stimulation in treatment-resistant depression.

IF 2.6 4区医学 Q3 NEUROSCIENCES Acta Neuropsychiatrica Pub Date : 2014-12-01 Epub Date: 2014-09-18 DOI:10.1017/neu.2014.22

Donald F Smith

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引用次数: 11

Abstract

Objective: Deep brain stimulation is currently an experimental treatment for major depressive disorder. Information is lacking, however, on how sham responding may affect efficacy. This article applies exploratory meta-analysis to address that topic.

Methods: Data on benefits of deep brain electrical stimulation come from a recent review. Stimulated brain regions included subgenual cingulate, capsular interna, nucleus accumbens, and medial forebrain bundle. Expert opinion plus random number software was used to generate hypothetical values for sham responding.

Results: An effect size of 1.71 (95% CI: 1.47-1.96) was obtained for deep brain stimulation versus sham treatment in patients suffering from long-term treatment-resistant depression.

Conclusion: Preliminary findings on deep brain electrical stimulation suggest that the procedure may be 71% more effective than sham treatment. Expressing these findings as patients-needed-to-treat, deep brain electrical stimulation is required by 2.9 patients with long-term treatment-resistant depression in order for one of them to benefit.

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脑深部电刺激治疗难治性抑郁症的探索性meta分析。

目的:脑深部电刺激是目前治疗重度抑郁症的一种实验性治疗方法。然而，缺乏关于虚假反应如何影响疗效的信息。本文采用探索性元分析来解决这个问题。方法:有关深部脑电刺激益处的数据来自最近的一篇综述。受刺激的脑区包括属下扣带、囊内、伏隔核和内侧前脑束。采用专家意见加随机数软件生成假设值进行假响应。结果:在长期难治性抑郁症患者中，深部脑刺激与假性治疗的效应值为1.71 (95% CI: 1.47-1.96)。结论:脑深部电刺激的初步研究结果表明，该程序可能比假治疗有效71%。将这些发现表达为患者需要治疗，2.9名长期治疗难治性抑郁症患者需要深部脑电刺激，以使其中一人受益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Neuropsychiatrica NEUROSCIENCES-PSYCHIATRY

自引率

5.30%

发文量

期刊介绍： Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.