Design strategies of biodegradable scaffolds for tissue regeneration.

IF 2.3 Q3 ENGINEERING, BIOMEDICAL Biomedical Engineering and Computational Biology Pub Date : 2014-05-08 eCollection Date: 2014-01-01 DOI:10.4137/BECB.S10961
Khalil N Bitar, Elie Zakhem
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引用次数: 47

Abstract

There are numerous available biodegradable materials that can be used as scaffolds in regenerative medicine. Currently, there is a huge emphasis on the designing phase of the scaffolds. Materials can be designed to have different properties in order to match the specific application. Modifying scaffolds enhances their bioactivity and improves the regeneration capacity. Modifications of the scaffolds can be later characterized using several tissue engineering tools. In addition to the material, cell source is an important component of the regeneration process. Modified materials must be able to support survival and growth of different cell types. Together, cells and modified biomaterials contribute to the remodeling of the engineered tissue, which affects its performance. This review focuses on the recent advancements in the designs of the scaffolds including the physical and chemical modifications. The last part of this review also discusses designing processes that involve viability of cells.

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生物可降解组织再生支架的设计策略。
有许多可用的可生物降解材料可以用作再生医学的支架。目前,人们非常重视支架的设计阶段。材料可以设计成具有不同的性能,以匹配特定的应用。改性支架增强了其生物活性,提高了再生能力。支架的修饰可以稍后使用几种组织工程工具进行表征。除了材料外,细胞来源也是再生过程的重要组成部分。修饰材料必须能够支持不同类型细胞的生存和生长。细胞和改良的生物材料共同促进工程组织的重塑,从而影响其性能。本文综述了近年来支架设计的最新进展,包括物理修饰和化学修饰。本综述的最后一部分还讨论了涉及细胞活力的设计过程。
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