Extended Fixed Attribute Dynamics Method and an Illustrative Application in Bio-demographic-genetic Analysis on Longevity.

Yi Zeng
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Abstract

This chapter presents and discuss the extended Fixed Attributes Dynamics (FAD) method to estimate the independent effect of a genetic variant (or other fixed attribute) in the absence of another relevant genetic variant (or another relevant fixed attribute), the joint effects when both are present and the effects of interactions between them. We present an illustrative application of the extended FAD method for estimating the general, independent and joint effects of the FOXO genotypes on longevity, based on the genotypic data of 760 centenarians from the Chinese Longitudinal Healthy Longevity Survey, and the 1,060 middle-age controls. We also discuss the strengths and limitations of the FAD method.

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扩展固定属性动力学方法及其在寿命生物人口-遗传分析中的实例应用。
本章介绍并讨论了扩展的固定属性动力学(FAD)方法,用于估计在没有另一个相关的遗传变异(或另一个相关的固定属性)的情况下,遗传变异(或其他固定属性)的独立影响,两者存在时的联合影响以及它们之间相互作用的影响。本文基于中国健康长寿纵向调查的760名百岁老人和1060名中年对照者的基因型数据,应用扩展FAD方法估计FOXO基因型对寿命的总体、独立和联合影响。我们还讨论了FAD方法的优点和局限性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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