High Rate of Multiple Concurrent Human Papillomavirus Infections among HIV-Uninfected South African Adolescents.

Journal of immunological techniques in infectious diseases Pub Date : 2013-01-01

David Adler, Fatima Laher, Melissa Wallace, Katherine Grzesik, Heather Jaspan, Linda-Gail Bekker, Glenda Gray, Ziyaad Valley-Omar, Bruce Allan, Anna-Lise Williamson

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Abstract

Background: The epidemiology and impact of multiple concurrent Human papillomavirus (HPV) infections on the natural history of cervical disease is uncertain, but could have significant implications for cervical cancer prevention and HPV vaccination strategies.

Methods: A cross-sectional prevalence study was conducted to determine the overall prevalence of HPV and the rate of multiple concurrent HPV infections, in a cohort of sexually active HIV-uninfected South African adolescents. HPV genotyping was performed using the polymerase chain reaction.

Results: Overall prevalence of HPV was 64.1%. Multiple concurrent HPV infections were found in 43.6% of participants and 68% of HPV-infected participants. Non-vaccine high-risk HPV (HR-HPV) genotypes were found much more often than vaccine types (HPV16 and HPV18).

Conclusions: Our cohort of young South African females was found to have a high overall prevalence of HPV and multiple concurrent HPV infections. Most HR-HPV infections found were genotypes other than HPV16 or HPV18.

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未感染艾滋病毒的南非青少年多重并发人乳头瘤病毒感染率高。

背景:多种并发人乳头瘤病毒(HPV)感染的流行病学和对宫颈疾病自然史的影响尚不确定，但可能对宫颈癌预防和HPV疫苗接种策略具有重要意义。方法:在一组性活跃的未感染hiv的南非青少年中，进行了一项横断面流行病学研究，以确定HPV的总体流行率和多重并发HPV感染率。采用聚合酶链反应进行HPV基因分型。结果:HPV总患病率为64.1%。在43.6%的参与者和68%的HPV感染参与者中发现多重并发HPV感染。非疫苗高危型HPV (HR-HPV)基因型比疫苗型(HPV16和HPV18)更常见。结论:我们的年轻南非女性队列发现HPV和多重并发HPV感染的总体患病率很高。大多数HR-HPV感染是HPV16或HPV18以外的基因型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of immunological techniques in infectious diseases

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