Localization of S100A2, S100A4, S100A6, S100A7, and S100P in the human hair follicle.

Fukuoka igaku zasshi = Hukuoka acta medica Pub Date : 2014-07-01

Chikage Mitoma, Futoshi Kohda, Yukihiro Mizote, Akira Miake, Ayako Ijichi, Saho Kawahara, Miki Kohno, Hiroko Sonoyama, Yasutaka Mitamura, Yumiko Kaku, Hiroko Inoue, Yoshiko Sasaki, Fumitaka Ohno, Noriko Okabe, Nobutoshi Take, Mika Mizote, Akiko Masuda, Masutaka Furue

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Abstract

The hair follicle is a highly differentiated structure. In this study, we examined immunohistological localization of S100A2, S100A4, S100A6, S100A7, and S100P using specific monoclonal antibodies. S100A2 was strongly expressed in the entire outer-root sheath (ORS), but more weakly in cuticle and medulla in the bulb. S100A6, S100A7, and S100P were expressed in the innermost cells of ORS. The cuticular area was weakly positive for S100A2, S100A6, S100A7, and S100P. S100A4 was expressed in dendritic Langerhans cells and melanocytes. Sebaceous cells were variably immunopositive for S100A2, S100A6, and S100A7. A subset of dermal papilla cells expressed S100A4 and S100A6. None of the antibodies labeled the inner-root sheath. The distinct spatiostructural distributions of the S100 family proteins suggest that each protein is differentially involved in the physiological function of normal hair follicles.

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S100A2、S100A4、S100A6、S100A7、S100P在人毛囊中的定位。

毛囊是一个高度分化的结构。在本研究中，我们使用特异性单克隆抗体检测了S100A2、S100A4、S100A6、S100A7和S100P的免疫组织学定位。S100A2在整个根外鞘(ORS)中表达强烈，而在鳞茎的角质层和髓质中表达较弱。S100A6、S100A7、S100P在ORS最内层细胞中表达。表皮面积S100A2、S100A6、S100A7、S100P呈弱阳性。S100A4在树突状朗格汉斯细胞和黑色素细胞中表达。皮脂腺细胞对S100A2、S100A6和S100A7的免疫呈不同程度的阳性。一部分真皮乳头细胞表达S100A4和S100A6。没有抗体标记内根鞘。S100家族蛋白的不同空间结构分布表明，每种蛋白在正常毛囊的生理功能中都有不同的参与。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Fukuoka igaku zasshi = Hukuoka acta medica

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