Severe/Extreme Hypertriglyceridemia and LDL Apheretic Treatment: Review of the Literature, Original Findings.

Cholesterol Pub Date : 2014-01-01 Epub Date: 2014-12-16 DOI:10.1155/2014/109263
Olga Diakoumakou, Georgios Hatzigeorgiou, Nikos Gontoras, Maria Boutsikou, Vana Kolovou, Sophie Mavrogeni, Vassiliki Giannakopoulou, Genovefa D Kolovou
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引用次数: 14

Abstract

Hypertriglyceridemia (HTG) is a feature of numerous metabolic disorders including dyslipidemias, metabolic syndrome, and diabetes mellitus type 2 and can increase the risk of premature coronary artery disease. HTG may also be due to genetic factors (called primary HTG) and particularly the severe/extreme HTG (SEHTG), which is a usually rare genetic disorder. Even rarer are secondary cases of SEHTG caused by autoimmune disease. This review considers the causes of SEHTG, and their management including treatment with low density lipoprotein apheresis and analyzes the original findings.

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严重/极端高甘油三酯血症和低密度脂蛋白的治疗:文献回顾,原始发现。
高甘油三酯血症(HTG)是许多代谢性疾病的特征,包括血脂异常、代谢综合征和2型糖尿病,并可增加过早冠状动脉疾病的风险。HTG也可能是由于遗传因素(称为原发性HTG),特别是严重/极端HTG (SEHTG),这是一种罕见的遗传疾病。由自身免疫性疾病引起的继发性SEHTG病例更为罕见。本文综述了SEHTG的病因及其治疗方法,包括低密度脂蛋白分离治疗,并分析了最初的发现。
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