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{"title":"Expression Data Analysis with Reactome","authors":"Steve Jupe, Antonio Fabregat, Henning Hermjakob","doi":"10.1002/0471250953.bi0820s49","DOIUrl":null,"url":null,"abstract":"<p>The Reactome database of curated biological pathways provides a tool for visualizing user-supplied expression data as an overlay on pathway diagrams, thereby affording an effective means to examine expression of the constituents of the pathway and determine whether all that are necessary are present. Several experiments can be visualized in succession, to determine whether expression changes with experimental conditions, a useful feature for examining a time-course, dose-response, or disease progression. © 2015 by John Wiley & Sons, Inc.</p>","PeriodicalId":10958,"journal":{"name":"Current protocols in bioinformatics","volume":"49 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/0471250953.bi0820s49","citationCount":"16","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current protocols in bioinformatics","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/0471250953.bi0820s49","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 16
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Abstract
The Reactome database of curated biological pathways provides a tool for visualizing user-supplied expression data as an overlay on pathway diagrams, thereby affording an effective means to examine expression of the constituents of the pathway and determine whether all that are necessary are present. Several experiments can be visualized in succession, to determine whether expression changes with experimental conditions, a useful feature for examining a time-course, dose-response, or disease progression. © 2015 by John Wiley & Sons, Inc.
Reactome表达数据分析
Reactome数据库提供了一种工具,可以将用户提供的表达数据可视化,作为通路图的覆盖层,从而提供了一种有效的方法来检查通路成分的表达,并确定是否所有必要的成分都存在。几个实验可以连续可视化,以确定表达是否随实验条件而变化,这是检查时间过程、剂量反应或疾病进展的有用特征。©2015 by John Wiley &儿子,Inc。
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