Photoacoustic tomography: principles and advances.

IF 6.1 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC Electromagnetic waves (Cambridge, Mass.) Pub Date : 2014-01-01 DOI:10.2528/pier14032303
Jun Xia, Junjie Yao, Lihong V Wang
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Abstract

Photoacoustic tomography (PAT) is an emerging imaging modality that shows great potential for preclinical research and clinical practice. As a hybrid technique, PAT is based on the acoustic detection of optical absorption from either endogenous chromophores, such as oxy-hemoglobin and deoxy-hemoglobin, or exogenous contrast agents, such as organic dyes and nanoparticles. Because ultrasound scatters much less than light in tissue, PAT generates high-resolution images in both the optical ballistic and diffusive regimes. Over the past decade, the photoacoustic technique has been evolving rapidly, leading to a variety of exciting discoveries and applications. This review covers the basic principles of PAT and its different implementations. Strengths of PAT are highlighted, along with the most recent imaging results.

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光声断层扫描:原理与进展。
光声断层成像(PAT)是一种新兴的成像模式,在临床前研究和临床实践中显示出巨大的潜力。作为一种混合技术,光声断层成像是基于对内源性发色团(如氧合血红蛋白和脱氧血红蛋白)或外源性造影剂(如有机染料和纳米粒子)的光吸收进行声学检测。由于超声波在组织中的散射远小于光,因此 PAT 可在光学弹道和扩散两种情况下生成高分辨率图像。过去十年来,光声技术发展迅速,带来了各种令人兴奋的发现和应用。本综述介绍了光声技术的基本原理及其不同的实现方法。重点介绍了光声技术的优势以及最新的成像结果。
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