{"title":"Photoacoustic tomography: principles and advances.","authors":"Jun Xia, Junjie Yao, Lihong V Wang","doi":"10.2528/pier14032303","DOIUrl":null,"url":null,"abstract":"<p><p>Photoacoustic tomography (PAT) is an emerging imaging modality that shows great potential for preclinical research and clinical practice. As a hybrid technique, PAT is based on the acoustic detection of optical absorption from either endogenous chromophores, such as oxy-hemoglobin and deoxy-hemoglobin, or exogenous contrast agents, such as organic dyes and nanoparticles. Because ultrasound scatters much less than light in tissue, PAT generates high-resolution images in both the optical ballistic and diffusive regimes. Over the past decade, the photoacoustic technique has been evolving rapidly, leading to a variety of exciting discoveries and applications. This review covers the basic principles of PAT and its different implementations. Strengths of PAT are highlighted, along with the most recent imaging results.</p>","PeriodicalId":90819,"journal":{"name":"Electromagnetic waves (Cambridge, Mass.)","volume":null,"pages":null},"PeriodicalIF":6.1000,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311576/pdf/nihms610461.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Electromagnetic waves (Cambridge, Mass.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2528/pier14032303","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
引用次数: 0
Abstract
Photoacoustic tomography (PAT) is an emerging imaging modality that shows great potential for preclinical research and clinical practice. As a hybrid technique, PAT is based on the acoustic detection of optical absorption from either endogenous chromophores, such as oxy-hemoglobin and deoxy-hemoglobin, or exogenous contrast agents, such as organic dyes and nanoparticles. Because ultrasound scatters much less than light in tissue, PAT generates high-resolution images in both the optical ballistic and diffusive regimes. Over the past decade, the photoacoustic technique has been evolving rapidly, leading to a variety of exciting discoveries and applications. This review covers the basic principles of PAT and its different implementations. Strengths of PAT are highlighted, along with the most recent imaging results.
光声断层成像(PAT)是一种新兴的成像模式,在临床前研究和临床实践中显示出巨大的潜力。作为一种混合技术,光声断层成像是基于对内源性发色团(如氧合血红蛋白和脱氧血红蛋白)或外源性造影剂(如有机染料和纳米粒子)的光吸收进行声学检测。由于超声波在组织中的散射远小于光,因此 PAT 可在光学弹道和扩散两种情况下生成高分辨率图像。过去十年来,光声技术发展迅速,带来了各种令人兴奋的发现和应用。本综述介绍了光声技术的基本原理及其不同的实现方法。重点介绍了光声技术的优势以及最新的成像结果。