Serum alpha-fetoprotein may have a significant role in the surveillance of hepatocellular carcinoma in hepatitis B endemic areas.

Hepato-gastroenterology Pub Date : 2015-03-01

Dong Hyun Sinn, Jieun Yi, Moon Seok Choi, Yu Jin Kim, Geum-Youn Gwak, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik, Byung Chul Yoo

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Abstract

Background/aims: The role of serum alpha-fetoprotein (AFP) determination in hepatocellular carcinoma (HCC) surveillance is controversial.

Methods: We reviewed a total of 132 patients (mean age 57.8 ± 9.6, males = 101 (76%); HBsAg positive = 109 (82.6%); cirrhosis = 94 (71.2%)) who were diagnosed with HCC during regular surveillance test with ultrasound (US) and AFP.

Results: The primary mode of tumor detection was US only in 51.5%, US and AFP in 22.0%, AFP only in 19.7%, and incidental in 6.8% of patients. US detected 68.5% of tumor diagnosed at early stage, which was significantly lower than tumor beyond-early stage (85.0%, p = 0.048). AFP doubling (an increase in AFP level more than double from a prior surveillance) was more frequently observed in HBV-related HCC (47.7%) than HCV-related HCC (11.8%, p = 0.009). The AFP increased sensitivity by 19.7% for all patients; 28.0% for HBV-related early stage HCC patients.

Conclusions: This result suggest that serum AFP measurements may have a significant role in increasing sensitivity in HCC surveillance, especially for detecting early stage HBV-related HCC.

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血清甲胎蛋白在乙型肝炎流行地区的肝细胞癌监测中可能具有重要作用。

背景/目的:血清甲胎蛋白(AFP)测定在肝细胞癌(HCC)监测中的作用存在争议。方法:回顾性分析132例患者，平均年龄57.8±9.6岁，男性101例(76%);HBsAg阳性= 109 (82.6%);肝硬化= 94例(71.2%)，在常规超声(US)和AFP监测试验中诊断为HCC。结果:肿瘤的主要检测方式为US (51.5%)， US和AFP (22.0%)， AFP(19.7%)，偶发(6.8%)。早期肿瘤的US检出率为68.5%，显著低于超早期肿瘤(85.0%，p = 0.048)。甲胎蛋白加倍(甲胎蛋白水平比先前监测增加一倍以上)在hbv相关HCC中更为常见(47.7%)，而在hcv相关HCC中更常见(11.8%，p = 0.009)。AFP使所有患者的敏感性增加19.7%;28.0%为hbv相关的早期HCC患者。结论:该结果提示血清AFP检测可能在提高HCC监测敏感性方面具有重要作用，特别是在检测早期hbv相关HCC方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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