Serum high-sensitivity C-reactive protein are associated with HBV replication, liver damage and fibrosis in patients with chronic hepatitis B.

Hepato-gastroenterology Pub Date : 2015-03-01

Li-Na Ma, Xiao-Yan Liu, Xia Luo, Yan-Chao Hu, Shuai-Wei Liu, Yuan-Yuan Tang, Jin-Liang Pan, Xiang-Chun Ding

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Abstract

Background/aims: The aim of this study was to explore the potential role of serum high-sensitivity C-reactive protein (hs-CRP) in the pathogenic process of chronic hepatitis B.

Methodology: A total of 380 patients with chronic hepatitis B were included in this study. All patients received the concentrations of serum hs-CRP, Hepatitis B sero-markers, serum HBV-DNA loads, liver function parameters and liver stiffness were measured, and in which 172 patients undertaken liver biopsy and immunohistochemistry analysis.

Results: Serum hs-CRP concentration in patients with the chronic hepatitis B (2.38 ± 5.52) was significantly higher than healthy controls (0.60 ± 0.53), P < 0.05. The area under ROC curve in fibrosis S4 and S3 is 0.826 and 0.78. The sensitivity and specificity of hs-CRP for fibrosis S3 and S4 diagnosis were 81.8%, 80% and 73.4%, 76.2% respectively (cut off: 1.01 mg/ml, 1.11 mg/l).

Conclusions: C-reactive Protein are associated with HBV replication, liver damage and fibrosis in patients with chronic hepatitis B, and serum High-sensitivity C-reactive Protein may be a marker for diagnosing significant fibrosis in patients with chronic hepatitis B, and can reflect the severity of liver damage.

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慢性乙型肝炎患者血清高敏c反应蛋白与HBV复制、肝损伤和纤维化相关

背景/目的:本研究旨在探讨血清高敏c反应蛋白(hs-CRP)在慢性乙型肝炎发病过程中的潜在作用。方法:本研究共纳入380例慢性乙型肝炎患者。所有患者均接受血清hs-CRP浓度、乙型肝炎血清标志物、血清HBV-DNA负荷、肝功能参数和肝脏硬度测定，其中172例患者进行肝活检和免疫组织化学分析。结果:慢性乙型肝炎患者血清hs-CRP浓度(2.38±5.52)显著高于健康对照组(0.60±0.53)，P < 0.05。S4和S3纤维化的ROC曲线下面积分别为0.826和0.78。hs-CRP诊断纤维化S3、S4的敏感性和特异性分别为81.8%、80%和73.4%、76.2%(截值分别为1.01 mg/ml、1.11 mg/l)。结论:c -反应蛋白与慢性乙型肝炎患者HBV复制、肝损伤及纤维化相关，血清高敏c -反应蛋白可作为诊断慢性乙型肝炎患者显著纤维化的标志物，并可反映肝损伤的严重程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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