{"title":"[Case of law-evading herbs poisoning that induced shock and myocardial damage].","authors":"Yoshihiko Nakamura, Minoru Nakano, Mitsunobu Nakamura, Dai Miyazaki, Satoshi Okamori, Hisashi Akuzawa, Masahiro Yuasa","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Law-evading herbs may induce poisoning symptoms, especially when they contain synthetic cannabinoids. However, their detailed pharmacological effects have not yet been clarified. Some reports have previously described symptoms of poisoning, but only a few reports have so far described shock and myocardial damage (MD). We experienced a case of shock and MD in a patient who had smoked law-evading herbs. A 61-year-old male presented at an emergency department 8 hours after smoking law-evading herbs (Rush Trip, High Men Monster) with chest pain. A vasopressor agent was administered to treat shock and antiarrhythmic drugs were administered due to ventricular arrhythmia. The contents of the law-evading herbs were unknown, so an in-hospital follow-up was conducted to treat the patient's symptoms. The follow-up blood test showed an increased level of cardiac enzymes, which thereafter demonstrated a spontaneous remission. The systemic conditions tended to improve and the patient was discharged from the hospital on the 5th hospital day. The contents of the law-evading herbs in question were thereafter,analyzed, and synthetic cannabinoids (JWH-210, JWH-081 and JWH-122) as well as caffeine were detected. The cause for the poisoning symptoms were suspected to be the presence of synthetic cannabinoids and caffeine. Such law-evading herbs may contain synthetic cannabinoids and caffeine which both may induce shock and MD.</p>","PeriodicalId":10299,"journal":{"name":"Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Law-evading herbs may induce poisoning symptoms, especially when they contain synthetic cannabinoids. However, their detailed pharmacological effects have not yet been clarified. Some reports have previously described symptoms of poisoning, but only a few reports have so far described shock and myocardial damage (MD). We experienced a case of shock and MD in a patient who had smoked law-evading herbs. A 61-year-old male presented at an emergency department 8 hours after smoking law-evading herbs (Rush Trip, High Men Monster) with chest pain. A vasopressor agent was administered to treat shock and antiarrhythmic drugs were administered due to ventricular arrhythmia. The contents of the law-evading herbs were unknown, so an in-hospital follow-up was conducted to treat the patient's symptoms. The follow-up blood test showed an increased level of cardiac enzymes, which thereafter demonstrated a spontaneous remission. The systemic conditions tended to improve and the patient was discharged from the hospital on the 5th hospital day. The contents of the law-evading herbs in question were thereafter,analyzed, and synthetic cannabinoids (JWH-210, JWH-081 and JWH-122) as well as caffeine were detected. The cause for the poisoning symptoms were suspected to be the presence of synthetic cannabinoids and caffeine. Such law-evading herbs may contain synthetic cannabinoids and caffeine which both may induce shock and MD.
逃避法律的草药可能会引起中毒症状,特别是当它们含有合成大麻素时。然而,其详细的药理作用尚未阐明。以前有一些报告描述了中毒症状,但迄今为止只有少数报告描述了休克和心肌损伤(MD)。我们经历了一个病例休克和MD的病人谁抽逃避法律的草药。一名61岁男性在吸食非法草药(Rush Trip, High Men Monster) 8小时后出现胸痛。由于室性心律失常,给予血管加压剂治疗休克和抗心律失常药物。由于不知道这些非法草药的成分,因此对患者进行了住院随访,以治疗患者的症状。随后的血液检查显示心脏酶水平升高,随后表现出自发缓解。全身情况趋于好转,患者于第5天出院。随后,对这些非法草药的含量进行了分析,检测出了合成大麻素(JWH-210、JWH-081和JWH-122)和咖啡因。中毒症状的原因被怀疑是合成大麻素和咖啡因的存在。这些逃避法律的草药可能含有合成大麻素和咖啡因,两者都可能导致休克和MD。