Cerebrolysin Accelerates Metamorphosis and Attenuates Aging-Accelerating Effect of High Temperature in Drosophila Melanogaster.

American journal of neuroprotection and neuroregeneration Pub Date : 2014-10-01 DOI:10.1166/ajnn.2014.1083

V Navrotskaya, G Oxenkrug, L Vorobyova, H Sharma, D Muresanu, P Summergrad

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引用次数: 5

Abstract

Cerebrolysin® (CBL) is a neuroprotective drug used for the treatment of neurodegenerative diseases. CBL's mechanisms of action remain unclear. Involvement of tryptophan (TRP)-kynurenine (KYN) pathway in neuroprotective effect of CBL might be suggested considering that modulation of KYN pathway of TRP metabolism by CBL, and protection against eclosion defect and prolongation of life span of Drosophila melanogaster with pharmacologically or genetically-induced down-regulation of TRP conversion into KYN. To investigate possible involvement of TRP-KYN pathway in mechanisms of neuroprotective effect of CBL, we evaluated CBL effects on metamorphosis and life span of Drosophila melanogaster maintained at 23 °C and 28 °C ambient temperature. CBL accelerated metamorphosis, exerted strong tendency (p = 0.04) to prolong life span in female but not in male flies, and attenuated aging-accelerating effect of high (28 °C) ambient temperature in both female and male flies. Further research of CBL effects on metamorphosis and resistance to aging-accelerating effect of high temperature might offer new insights in mechanisms of its neuroprotective action and expand its clinical applications.

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脑溶素加速黑腹果蝇的变态和减弱高温的加速衰老作用。

脑溶素®(CBL)是一种用于治疗神经退行性疾病的神经保护药物。CBL的作用机制尚不清楚。考虑到CBL通过调节TRP代谢的KYN通路，通过药理学或基因诱导下调TRP向KYN的转化，对黑腹果蝇的羽化缺陷和延长寿命起到保护作用，提示CBL可能参与了色氨酸-犬尿氨酸通路的神经保护作用。为了探讨TRP-KYN通路可能参与CBL神经保护作用的机制，我们评估了CBL在23℃和28℃环境温度下对黑腹果蝇(Drosophila melanogaster)变态和寿命的影响。CBL加速了果蝇的蜕变，在雌性果蝇中有较强的延长寿命倾向(p = 0.04)，而在雄性果蝇中没有，并且在雌性和雄性果蝇中都减弱了高温(28℃)的加速衰老作用。进一步研究CBL在高温下的变态和抗衰老作用，可能为其神经保护作用的机制提供新的见解，并扩大其临床应用。

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American journal of neuroprotection and neuroregeneration

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