Vitiligo in adults and children: surgical interventions.

BMJ clinical evidence Pub Date : 2015-03-20

Rubeta Matin

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Abstract

Introduction: Vitiligo is an acquired skin disorder characterised by white (depigmented) patches in the skin, due to the loss of functioning melanocytes. The extent and distribution of vitiligo often changes during the course of a person's lifetime and its progression is unpredictable.

Methods and outcomes: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of surgical interventions for vitiligo in adults and in children? We searched: Medline, Embase, The Cochrane Library, and other important databases up to April 2014 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).

Results: We found four studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.

Conclusions: In this systematic review we present information relating to the effectiveness and safety of the following interventions: blister grafts, cultured cellular transplantation, non-cultured cellular transplantation, punch/mini grafts, and split thickness skin grafts.

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成人和儿童白癜风:手术干预。

简介:白癜风是一种获得性皮肤疾病，其特征是皮肤上出现白色(脱色)斑块，原因是黑色素细胞功能丧失。白癜风的程度和分布通常在一个人的一生中发生变化，其进展是不可预测的。方法和结果:我们进行了一项系统回顾，旨在回答以下临床问题:成人和儿童白癜风手术干预的效果是什么?截至2014年4月，我们检索了Medline、Embase、The Cochrane Library和其他重要数据库(临床证据综述定期更新，请查看我们的网站以获取本综述的最新版本)。我们纳入了来自相关组织的危害警报，如美国食品和药物管理局(FDA)和英国药品和保健产品监管局(MHRA)。结果:我们发现四项研究符合我们的纳入标准。我们对干预措施的证据质量进行了GRADE评价。结论:在这篇系统综述中，我们介绍了以下干预措施的有效性和安全性:水疱移植、培养细胞移植、非培养细胞移植、穿孔/微型移植和裂厚皮肤移植。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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