Fábio Henrique de Gobbi Porto, Artur Martins Novaes Coutinho, Ana Lucia de Sá Pinto, Bruno Gualano, Fabio Luís de Souza Duran, Silvana Prando, Carla Rachel Ono, Lívia Spíndola, Maira Okada de Oliveira, Patrícia Helena Figuerêdo do Vale, Ricardo Nitrini, Carlos Alberto Buchpiguel, Sonia Maria Dozzi Brucki
{"title":"Effects of Aerobic Training on Cognition and Brain Glucose Metabolism in Subjects with Mild Cognitive Impairment.","authors":"Fábio Henrique de Gobbi Porto, Artur Martins Novaes Coutinho, Ana Lucia de Sá Pinto, Bruno Gualano, Fabio Luís de Souza Duran, Silvana Prando, Carla Rachel Ono, Lívia Spíndola, Maira Okada de Oliveira, Patrícia Helena Figuerêdo do Vale, Ricardo Nitrini, Carlos Alberto Buchpiguel, Sonia Maria Dozzi Brucki","doi":"10.3233/JAD-150033","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Aerobic training (AT) is a promising intervention for mild cognitive impairment (MCI).</p><p><strong>Objective: </strong>To evaluate the effects of AT on cognition and regional brain glucose metabolism (rBGM) in MCI patients.</p><p><strong>Methods: </strong>Subjects performed a twice-a-week, moderate intensity, AT program for 24 weeks. Assessment with ADAS-cog, a comprehensive neuropsychological battery, and evaluation of rBGM with positron emission tomography with 18F-fluorodeoxyglucose ([18F]FDG-PET) were performed before and after the intervention. Aerobic capacity was compared using the maximal oxygen consumption VO2max (mL/Kg/min). [18F]FDG-PET data were analyzed on a voxel-by-voxel basis with SPM8 software.</p><p><strong>Results: </strong>Forty subjects were included, with a mean (M) age of 70.3 (5.4) years and an initial Mini-Mental State Exam score of 27.4 (1.7). Comparisons using paired t-tests revealed improvements in the ADAS-cog (M difference: -2.7 (3.7), p < 0.001) and VO2max scores (M difference: 1.8 (2.0) mL/kg/min, p < 0.001). Brain metabolic analysis revealed a bilateral decrease in the rBGM of the dorsal anterior cingulate cortex, pFWE = 0.04. This rBGM decrease was negatively correlated with improvement in a visuospatial function/attentional test (rho =-0.31, p = 0.04). Several other brain areas also showed increases or decreases in rBGM. Of note, there was an increase in the retrosplenial cortex, an important node of the default mode network, that was negatively correlated with the metabolic decrease in the dorsal anterior cingulate cortex (r =-0.51, p = 0.001).</p><p><strong>Conclusion: </strong>AT improved cognition and changed rBGM in areas related to cognition in subjects with MCI.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/JAD-150033","citationCount":"28","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Alzheimer's Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3233/JAD-150033","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 28
Abstract
Background: Aerobic training (AT) is a promising intervention for mild cognitive impairment (MCI).
Objective: To evaluate the effects of AT on cognition and regional brain glucose metabolism (rBGM) in MCI patients.
Methods: Subjects performed a twice-a-week, moderate intensity, AT program for 24 weeks. Assessment with ADAS-cog, a comprehensive neuropsychological battery, and evaluation of rBGM with positron emission tomography with 18F-fluorodeoxyglucose ([18F]FDG-PET) were performed before and after the intervention. Aerobic capacity was compared using the maximal oxygen consumption VO2max (mL/Kg/min). [18F]FDG-PET data were analyzed on a voxel-by-voxel basis with SPM8 software.
Results: Forty subjects were included, with a mean (M) age of 70.3 (5.4) years and an initial Mini-Mental State Exam score of 27.4 (1.7). Comparisons using paired t-tests revealed improvements in the ADAS-cog (M difference: -2.7 (3.7), p < 0.001) and VO2max scores (M difference: 1.8 (2.0) mL/kg/min, p < 0.001). Brain metabolic analysis revealed a bilateral decrease in the rBGM of the dorsal anterior cingulate cortex, pFWE = 0.04. This rBGM decrease was negatively correlated with improvement in a visuospatial function/attentional test (rho =-0.31, p = 0.04). Several other brain areas also showed increases or decreases in rBGM. Of note, there was an increase in the retrosplenial cortex, an important node of the default mode network, that was negatively correlated with the metabolic decrease in the dorsal anterior cingulate cortex (r =-0.51, p = 0.001).
Conclusion: AT improved cognition and changed rBGM in areas related to cognition in subjects with MCI.
期刊介绍:
The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.