Amedeo Amedei, Nicola Pimpinelli, Alessia Grassi, Chiara Della Bella, Elena Niccolai, Simona Brancati, Marisa Benagiano, Sofia D'Elios, Alberto Bosi, Mario M D'Elios
{"title":"Skin CD30(+) T cells and circulating levels of soluble CD30 are increased in patients with graft versus host disease.","authors":"Amedeo Amedei, Nicola Pimpinelli, Alessia Grassi, Chiara Della Bella, Elena Niccolai, Simona Brancati, Marisa Benagiano, Sofia D'Elios, Alberto Bosi, Mario M D'Elios","doi":"10.1007/s13317-013-0054-7","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To determine serum soluble CD30 (sCD30) levels in patients with graft versus host disease (GVHD).</p><p><strong>Methods: </strong>Serum soluble CD30 levels and IgE levels were assayed by a sensitive ELISA in 57 patients with bone marrow transplantation, and in 44 healthy controls. We analyzed the type of effector T cells in patients with GVHD.</p><p><strong>Results: </strong>Serum levels of sCD30 and serum IgE levels were significantly higher (p values <0.05) in patients with acute and chronic GVHD than in healthy controls. We found that CD30(+) T-cells are present in the skin of patients with GVHD.</p><p><strong>Conclusion: </strong>These results suggest that serum sCD30 levels may be helpful for the management of patients with bone marrow transplantation.</p>","PeriodicalId":8655,"journal":{"name":"Auto-Immunity Highlights","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2013-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13317-013-0054-7","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Auto-Immunity Highlights","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s13317-013-0054-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2014/6/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 5
Abstract
Objective: To determine serum soluble CD30 (sCD30) levels in patients with graft versus host disease (GVHD).
Methods: Serum soluble CD30 levels and IgE levels were assayed by a sensitive ELISA in 57 patients with bone marrow transplantation, and in 44 healthy controls. We analyzed the type of effector T cells in patients with GVHD.
Results: Serum levels of sCD30 and serum IgE levels were significantly higher (p values <0.05) in patients with acute and chronic GVHD than in healthy controls. We found that CD30(+) T-cells are present in the skin of patients with GVHD.
Conclusion: These results suggest that serum sCD30 levels may be helpful for the management of patients with bone marrow transplantation.
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