{"title":"[Antiapoptotic effect of gangliosides on PC12 cells exposed to bacterial lipopolysaccharide].","authors":"L V Bayunova, G G Parnova, N F Avrova","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Lipopolysaccharide (LPS) from Escherichia coli of the 0111:B4 serotype was shown to exert the apoptotic effect on PC12 neuronal cells at concentrations of 0.1 and 0.125 mg/ml in DMEM (serum free medium). GD1a and GM1 gangliosides at a concentration of 100 μM were found to raise the PC12 cell viability and decrease the percentage of PC12 cells in the late apoptotic phase after exposure to LPS.</p>","PeriodicalId":24017,"journal":{"name":"Zhurnal evoliutsionnoi biokhimii i fiziologii","volume":"51 2","pages":"88-94"},"PeriodicalIF":0.0000,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhurnal evoliutsionnoi biokhimii i fiziologii","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Lipopolysaccharide (LPS) from Escherichia coli of the 0111:B4 serotype was shown to exert the apoptotic effect on PC12 neuronal cells at concentrations of 0.1 and 0.125 mg/ml in DMEM (serum free medium). GD1a and GM1 gangliosides at a concentration of 100 μM were found to raise the PC12 cell viability and decrease the percentage of PC12 cells in the late apoptotic phase after exposure to LPS.
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