Method for Evaluation of the Requirements of B-group Vitamins Using Tryptophan Metabolites in Human Urine.

IF 2.7 Q3 NEUROSCIENCES International Journal of Tryptophan Research Pub Date : 2015-04-19 eCollection Date: 2015-01-01 DOI:10.4137/IJTR.S24412

Katsumi Shibata, Junko Hirose, Tsutomu Fukuwatari

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Abstract

Tryptophan metabolism is directly involved with B-group vitamins such as vitamin B2, niacin, and vitamin B6, and indirectly with vitamin B1 and pantothenic acid. We evaluated the validity of requirements of B-group vitamins set by the Dietary Reference Intakes for the Japanese (DRI-J). We investigated the fate of dietary tryptophan in 10 Japanese adult men who ate the same diet based on DRI-J during a 4-week study. Vitamin mixtures were administered based on the amounts in the basal diet during weeks 2, 3, and 4. Daily urine samples were collected eight times (days 1 and 5 in each week). Administration of vitamin mixtures had no effect on tryptophan metabolites such as anthranilic acid, kynurenic acid, xanthurenic acid, 3-hydroxyanthranilic acid, and quinolinic acid within individuals. Surplus administration of B-group vitamins against DRI-J requirements did not elicit beneficial effects on tryptophan metabolism. Our findings supported the requirements of B-group vitamins set by the DRI-J.

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利用人体尿液中的色氨酸代谢物评估 B 族维生素需求量的方法。

色氨酸的代谢与维生素 B2、烟酸和维生素 B6 等 B 族维生素直接相关，与维生素 B1 和泛酸间接相关。我们评估了日本人膳食营养素参考摄入量（DRI-J）中规定的 B 族维生素需求量的有效性。在为期 4 周的研究中，我们调查了 10 名日本成年男性饮食中色氨酸的去向。在第 2、3 和 4 周期间，根据基础膳食中的含量摄入维生素混合物。每天收集尿样 8 次（每周的第 1 天和第 5 天）。服用维生素混合物对色氨酸代谢物（如蚁酸、犬尿氨酸、黄尿氨酸、3-羟基蚁酸和喹啉酸）没有影响。按照 DRI-J 的要求过量摄入 B 族维生素并不会对色氨酸代谢产生有益影响。我们的研究结果支持 DRI-J 确定的 B 族维生素需求量。

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