C-reactive protein and risk of breast cancer: A systematic review and meta-analysis.

IF 3.9 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Scientific Reports Pub Date : 2015-05-22 DOI:10.1038/srep10508

Lanwei Guo, Shuzheng Liu, Shaokai Zhang, Qiong Chen, Meng Zhang, Peiliang Quan, Jianbang Lu, Xibin Sun

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Abstract

Associations between elevated C-reactive protein (CRP) and breast cancer risk have been reported for many years, but the results remain controversial. To address this issue, a meta-analysis was therefore conducted. Eligible studies were identified by searching the PubMed and EMBASE up to December 2014. Study-specific risk estimates were combined using a random-effects model. Altogether fifteen cohort and case-control studies were included in this meta-analysis, involving a total of 5,286 breast cancer cases. The combined OR per natural log unit change in CRP for breast cancer was 1.16 (95% CI: 1.06-1.27). There was moderate heterogeneity among studies (I(2) = 45.9%). The association was stronger in Asian population (OR = 1.57, 95% CI: 1.25-1.96) compared to European (OR = 1.12, 95% CI: 1.02-1.23) and American (OR = 1.08, 95% CI: 1.01-1.16). Prediagnostic high-sensitivity CRP concentrations (OR = 1.22, 95% CI: 1.10-1.35) was superior to common CRP (OR = 1.08, 95% CI: 1.01-1.15) in predicting breast cancer risk. The meta-analysis indicated that elevated CRP levels was associated with increased risk of breast cancer. Further research effort should be performed to identify whether CRP, as a marker of inflammation, plays a direct role in breast carcinogenesis.

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c反应蛋白与乳腺癌风险：一项系统综述和荟萃分析。

c反应蛋白（CRP）升高与乳腺癌风险之间的关联多年来一直有报道，但结果仍存在争议。为了解决这个问题，我们进行了荟萃分析。通过检索PubMed和EMBASE（截止到2014年12月）确定符合条件的研究。研究特定的风险估计使用随机效应模型进行组合。这项荟萃分析共纳入了15项队列研究和病例对照研究，共涉及5286例乳腺癌病例。乳腺癌CRP每自然对数单位变化的综合OR为1.16 （95% CI: 1.06-1.27）。研究间存在中等异质性（I(2) = 45.9%）。与欧洲人群（OR = 1.12, 95% CI: 1.02-1.23）和美国人群（OR = 1.08, 95% CI: 1.01-1.16）相比，亚洲人群（OR = 1.57, 95% CI: 1.25-1.96）的相关性更强。诊断前高敏CRP浓度（OR = 1.22, 95% CI: 1.10-1.35）在预测乳腺癌风险方面优于普通CRP （OR = 1.08, 95% CI: 1.01-1.15）。荟萃分析表明，CRP水平升高与乳腺癌风险增加有关。应该进行进一步的研究以确定CRP作为炎症标志物是否在乳腺癌发生中起直接作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Scientific Reports Natural Science Disciplines-

CiteScore

7.50

自引率

4.30%

发文量

19567

审稿时长

3.9 months

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