Clinical significance of the laparoscopic bariatric surgeries for morbid obesity: initial 30 cases at a single institution in Japan.

Tetsuo Ikeda, Tomohiko Akahoshi, Morimasa Tomikawa, Ryouta Souzaki, Masatoshi Nomura, Noriyuki Sonoda, Rinko Nakayama, Chihiro Morita, Sadako Yamaguchi, Kenkichi Hashimoto, Yoshihiko Maehara, Makoto Hashizume
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Abstract

Background: Bariatric surgical procedures are becoming a standard treatment for morbid obesity in many western countries and in some Asian countries.

Aim: The aim of the current study was to evaluate the efficacy and safety of the initial 30 cases of bariatric surgical procedures performed for morbid obesity at a single institution in Japan.

Materials and methods: From March 2012 until September 2014, 30 bariatric surgical procedures were performed for morbid obesity at a single medical center (Kyushu University Hospital) in Japan.

Results: All of the operations procedures were planned laparoscopic procedures, and none required conversion to laparotomy. There were no perioperative or postoperative mortalities. Postoperative complications occurred in 3 patients: 1 patient developed an intra-abdominal abscess, 1 patient experienced temporary food intolerance, and 1 patient developed small bowel obstruction. The excessive body weight reduction rates after surgery at 1 month, 3 months, 6 months, and 1 year post-surgery were 26.1%, 39.2%, 41.7%, and 51.2%, respectively. The mean body mass index (BMI) at the same time points were 38.3%, 36.4%, 35.5%, and 31.4%, respectively. Eighteen patients had type II diabetes mellitus (T2DM). The mean preoperative fasting blood glucose levels were 169 ± 37 mg/dL. Following surgery, the blood glucose levels at 3, 6 and 12 months were 113 ± 12, 115 ± 22, and 110 ± 19, mg/dL, respectively. The preoperative HbA1c percentage was 7.9 ± 0.5. Following surgery, the HbA1c percentages at 3, 6, and 12 months were 6.9 ± 0.5, 6.2 ± 0.9, and 5.9 ± 0.6, respectively.

Conclusions: Bariatric surgical procedures are effective and safe for the treatment of morbid obesity. Our results indicate that the mechanism of improvement of diabetes and related diseases following bariatric surgical procedures is not simply as a result of calorie restriction and weight reduction.

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腹腔镜减肥手术治疗病态肥胖的临床意义:日本一家医院30例
背景:在许多西方国家和一些亚洲国家,减肥外科手术正在成为病态肥胖的标准治疗方法。目的:当前研究的目的是评估日本一家机构对30例病态肥胖患者进行减肥手术治疗的有效性和安全性。材料和方法:2012年3月至2014年9月,在日本一家医疗中心(九州大学医院)为病态肥胖患者进行了30例减肥手术。结果:所有手术均为计划的腹腔镜手术,无一例需要转开腹手术。无围手术期和术后死亡。3例患者出现术后并发症:1例出现腹内脓肿,1例出现暂时性食物不耐受,1例出现小肠梗阻。术后1个月、3个月、6个月、1年体重过度减轻率分别为26.1%、39.2%、41.7%、51.2%。同一时间点的平均体重指数(BMI)分别为38.3%、36.4%、35.5%和31.4%。18例患者合并2型糖尿病(T2DM)。术前平均空腹血糖水平为169±37 mg/dL。术后3、6、12个月血糖分别为113±12、115±22、110±19 mg/dL。术前HbA1c百分比为7.9±0.5。术后3、6、12个月的HbA1c百分比分别为6.9±0.5、6.2±0.9、5.9±0.6。结论:减肥手术治疗病态肥胖是安全有效的。我们的研究结果表明,减肥手术后糖尿病和相关疾病的改善机制不仅仅是热量限制和体重减轻的结果。
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