Flowing through the CRISPR-CAScade: Will genome editing boost cell therapies?

Molecular and cellular therapies Pub Date : 2013-11-06 eCollection Date: 2013-01-01
Uri Ben-David
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Abstract

Recent years have seen great advancements in genome editing technologies, allowing for efficient and specific targeting of DNA sequences into the genome. In parallel, advancements in stem cell research, and especially the ability to induce pluripotency in somatic cells, have brought stem cell-derived therapies closer to the clinic. In this commentary, I envision how groundbreaking genome editing technologies will influence stem cell biology research, paving the way to regenerative medicine with genetically engineered cells.

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通过crispr级联:基因组编辑会促进细胞治疗吗?
近年来,基因组编辑技术取得了巨大进步,可以有效和特定地将DNA序列靶向到基因组中。与此同时,干细胞研究的进步,特别是诱导体细胞多能性的能力,使干细胞衍生疗法更接近临床。在这篇评论中,我设想了开创性的基因组编辑技术将如何影响干细胞生物学研究,为基因工程细胞的再生医学铺平道路。
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